肠球菌遗传系的传播:一个健康的视角
Joana Monteiro Marques1,2, Mariana Coelho1,2, Andressa Rodrigues Santana1,2
1Centre for Interdisciplinary Research in Animal Health (CIISA), Faculty of Veterinary Medicine, University of Lisbon, Av. da Universidade Técnica de Lisboa, 1300-477 Lisbon, Portugal.
Antibiotics (Basel, Switzerland)
|July 29, 2023
概括
菌细菌是追踪人类,动物和环境健康的病原体的宝贵哨兵. 本综述考察了它们的特征,传播和遗传元素,这些都在"一健康"框架内进行.
科学领域:
- 微生物学 微生物学
- 一个健康,一个健康.
- 基因组学就是基因组学.
背景情况:
- 菌种类是人类和动物常见的肠道食用动物,广泛存在于水,土壤和食物中.
- 30多年来,肠球菌已经成为机会性病原体,导致医院相关感染,并被归类为ESKAPE病原体.
- 它们的适应性和基因获取能力使它们成为监测病原体传播的理想哨兵.
研究的目的:
- 审查肠球菌的健康状况和病原性特征.
- 通过各种来源 (临床,兽医,食品,环境) 识别常见的肠球菌克隆复合体.
- 分析全球高风险克隆体中毒性,耐药性和移动遗传元素的传播,在One Health连续体内.
主要方法:
- 对Enterococcus spp.的研究进行文献综述.
- 基因组特征的分析,包括毒性因子 (病毒组),抗生素耐药性基因 (抵抗组) 和移动遗传元素 (移动组).
- 检查克隆复合体及其在人类,动物和环境中的分布.
主要成果:
- 肠球菌表现出显著的适应能力,并具有有助于致病性的特征.
- 在临床,兽医,食品和环境样本中确定了常见的克隆复合体.
- 在全球范围内,在高风险克隆中观察到毒性,耐药性和移动基因元素的传播.
结论:
- 肠球菌是评估病原体传播和抗菌素耐药性的关键指标,在"一健康"框架内.
- 了解肠球菌的进化和传播对于公共卫生和兽医至关重要.
- 本次审查强调了病原体动态在人类,动物和环境卫生部门之间的相互联系.
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