原生 Aspergillus 内心炎:病例报告和文献综述
Claudio Caroselli1, Lorenzo Roberto Suardi1, Laura Besola2
1Infectious Diseases Unit, Department of Clinical and Experimental Medicine, Azienda Ospedaliera Universitaria Pisana, University of Pisa, 56126 Pisa, Italy.
Antibiotics (Basel, Switzerland)
|July 29, 2023
概括
一种罕见的真菌感染,Aspergillus内心炎,越来越多地被诊断为免疫功能低下的患者. 早期诊断和用抗真菌疗法和手术治疗对于生存至关重要.
科学领域:
- 传染性疾病 传染性疾病
- 菌类学 菌类学是指菌类学.
- 心脏病学 心脏病学
背景情况:
- 阿斯伯吉illus内心炎是假内心炎的第二大原因,并且在原生门中有事报告.
- 诊断的增加与高级诊断工具,如聚合酶链反应 (PCR) 相关.
研究的目的:
- 审查关于阿斯伯吉勒斯内心炎的文献,介绍比萨大学医院的一例病例.
- 突出这种机会性感染的风险因素,诊断方法和治疗策略.
主要方法:
- 从1950年到2022年的74个病例报告的文献综述.
- 对诊断方法的分析,包括血清银河胺,培养和PCR.
- 对治疗结果的评估,包括抗真菌疗法和心脏手术.
主要成果:
- 免疫受损状态是主要的危险因素.
- 观察到转移性感染的高率,特别是中枢神经系统的参与,以及死亡率.
- 诊断依赖于血清学标记物,培养物和PCR的组合.
结论:
- 阿斯伯吉illus内心炎需要一个高的怀疑指数在免疫功能低下的患者与阴性血液培养.
- 及时诊断和联合治疗 (抗真菌药物和手术) 对于提高生存率至关重要.
- 多学科团队对于管理这种具有挑战性的感染至关重要.
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