相关实验视频
Updated: Jul 21, 2025

11:41
Magnetic Tweezers for the Measurement of Twist and Torque
Published on: May 19, 2014
23.3K
TAFPred:从蛋白质序列预测扭曲角度波动
Md Wasi Ul Kabir1, Duaa Mohammad Alawad1, Avdesh Mishra2
1Computer Science Department, University of New Orleans, New Orleans, LA 70148, USA.
Biology
|July 29, 2023
概括
TAFPred是一种新的机器学习方法,可以直接从蛋白质序列中准确预测蛋白质扭矩角度波动. 这一进步有助于通过分析脊柱灵活性来了解蛋白质结构和功能.
科学领域:
- 结构生物学是结构生物学.
- 计算生物学是一种计算生物学.
- 在生物信息学中的机器学习.
背景情况:
- 蛋白质的灵活性对于功能至关重要,受到脊柱扭矩角度波动 (phi和psi) 的影响.
- 了解这些波动有助于预测蛋白质结构和功能,特别是当扭转角度作为约束时.
研究的目的:
- 开发一种机器学习方法 (TAFPred) 来直接预测由氨基酸序列产生的蛋白质扭曲角度波动.
- 根据现有的最先进的方法评估TAFPred的表现.
主要方法:
- 使用蛋白质序列作为直接输入.
- 包含了诸如障碍概率,位置特定的评分矩阵配置文件和二次结构概率等功能.
- 采用了一个优化的光梯度增强机回归器 (LightGBM) 模型.
主要成果:
- TAFPred实现了高精度,相关系数为0.746 (phi) 和0.737 (psi).
- 平均绝对误差为0.114 (phi) 和0.123 (psi) 的两个值.
- 在MAE和PCC中,在phi和psi两种角度都显示出明显的改进,而不是最先进的方法.
结论:
- TAFPred提供了一种强大而准确的方法来预测蛋白质扭矩角度波动.
- 该方法增强了对蛋白质结构灵活性的理解,并对基于结构的药物设计和蛋白质工程产生了影响.
相关概念视频
Angle of Twist - Elastic Range
358
Consider a cylindrical shaft with a length denoted by L and a consistent cross-sectional radius referred to as r. This shaft undergoes a torque at the free end. The highest shearing strain within the shaft is directly proportional to the twist angle and the radial distance from the shaft axis. When the shaft behaves elastically, this shearing strain can be articulated using variables such as the applied torque, radial distance, the polar moment of inertia, and the modulus of rigidity. By...
358
Unsymmetric Bending - Angle of Neutral Axis
352
Unsymmetrical bending occurs when a structural member is subjected to bending moments in a plane that does not align with the member's principal axes. This scenario typically arises in beams and other structural components when loads are applied at non-ideal angles, introducing complexities in stress analysis.
When a bending moment is applied at an angle θ concerning the vertical axis of a symmetrical member, it can be resolved into components along the member's principal...
When a bending moment is applied at an angle θ concerning the vertical axis of a symmetrical member, it can be resolved into components along the member's principal...
352
Angle of Twist: Problem Solving
349
An electric motor applies a torque of 700 N·m to an aluminum shaft, triggering a stable rotation. Two pulleys, B and C, are subjected to torques of 300 N·m and 400 N·m, respectively. The modulus of rigidity is provided as 25 GPa. With the knowledge of the length and diameter of each segment, the twist angle between the two pulleys can be computed. First, a section cut is made between pulleys B and C, and the cut cross-section is analyzed using a free-body diagram. Given that the...
349
Conservation of Protein Domains Over Different Proteins
10.9K
Protein domains are small structurally independent units that are part of a single amino acid chain. Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to...
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to...
10.9K
Torsional Pendulum
5.6K
A torsional pendulum involves the oscillation of a rigid body in which the restoring force is provided by the torsion in the string from which the rigid body is suspended. Ideally, the string should be massless; practically, its mass is much smaller than the rigid body's mass and is neglected.
As long as the rigid body's angular displacement is small, its oscillation can be modeled as a linear angular oscillation. The amplitude of the oscillation is an angle. The role of mass is played...
As long as the rigid body's angular displacement is small, its oscillation can be modeled as a linear angular oscillation. The amplitude of the oscillation is an angle. The role of mass is played...
5.6K
Torsion of Noncircular Members
159
Circular shafts undergoing torsional stress maintain their cross-sectional integrity due to their axisymmetric nature. This symmetry ensures an even distribution of stress, allowing the shaft to withstand torsion without distorting. In contrast, square bars, lacking this axial symmetry, experience significant distortion across their cross-sections when subjected to torsion, with the exception of along their diagonals and at lines connecting midpoints. A detailed examination of a cubic element...
159

