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由于恒定的光线导致的急性循环节障碍促进了鼠标海马中的卡斯巴1激活

Pikria Ketelauri¹, Katerina Scharov¹, Charlotte von Gall¹

¹Institute of Anatomy II, Medical Faculty, Heinrich-Heine-University (HHU), 40225 Düsseldorf, Germany.

|July 29, 2023

概括

夜间的人工光会扰乱哺乳动物的昼夜系统,影响免疫功能. 这项研究表明,持续暴露于光线会激活小鼠海马体中的炎症细胞,从而可能增加大脑的脆弱性.

科学领域:

神经科学是一个神经科学.
时间生物学时间生物学
免疫学免疫学免疫学

背景情况:

哺乳动物的昼夜系统调节生理学,受到环境线索,如光线.
夜间人工光 (ALAN) 的循环节障碍与疾病有关.
改变昼夜节律和免疫失调,包括炎症酶激活,在神经退行性疾病中可见.

研究的目的:

为了研究恒定光 (LL) 暴露对小鼠海马体炎症酶激活的影响.
了解昼夜干扰对大脑炎症细胞活动的直接影响.

主要方法:

小鼠被暴露在恒定的光线 (LL) 条件下.
在海马中分析了循环功率,运动活动和炎症酶激活标记物 (切割的caspase-1,pro-interleukins).

主要成果:

持续暴露于光线减少了小鼠的昼夜功率和运动运动活动.
在暴露于LL的小鼠的海马体中,切割的caspase-1水平显著升高.
没有检测到炎细胞原始化或亲介质素分裂的标志.

结论:

通过恒定光线引起的急性昼夜干扰会导致小鼠海马内炎症细胞组合.
这表明,昼夜干扰会使大脑开始工作,可能会增加对其他压力因素的脆弱性.

关键词:

卡斯帕斯1阶段昼夜时间的干扰.恒定的光线恒定的光线在海马体内,海马体炎症酶体 (inflammasomes) 是一种炎症酶体.它们包括interleukins和interleukins.

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