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肠-大脑轴作为多发性硬化症治疗目标

Ana Maria Buga¹, Vlad Padureanu², Anca-Lelia Riza^3,4

¹Department of Biochemistry, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.

|July 29, 2023

概括

准肠道微生物群可以通过减少氧化应激和神经炎症来帮助管理多发性硬化症 (MS). 未来的临床试验需要更大的队列和更长的观察期来验证.

科学领域:

神经科学是一个神经科学.
免疫学免疫学免疫学
微生物学微生物学

背景情况:

中枢神经系统 (CNS) 容易受到氧化应激的影响.
肠道微生物群失调可以引发氧化损伤,导致线粒体功能障碍,神经炎症和神经退行.
肠-大脑轴在调解这些过程中起着至关重要的作用,特别是在多发性硬化症 (MS) 中.

研究的目的:

审查MS中肠-大脑轴介导的氧化压力相关炎症的最新发现.
总结针对MS管理的微生物群相关氧化应激现有的临床试验.
为了确定适合的干预措施,组合和时间,以微生物群为基础的治疗.

主要方法:

现有临床试验的基于证据的审查.
对专注于MS肠道微生物群干预的研究进行分析.
评估试验设计,队列大小和研究的MS亚型.

主要成果:

越来越多的证据支持将肠道微生物群作为MS管理的有希望的战略.
大多数审查的试验集中在复发性复发性多发性硬化症 (RRMS),对其他多发性硬化症阶段的数据有限,如二次进展性多发性硬化症 (SPMS).
研究设计和结果的显著异质性凸显了对标准化,大规模临床验证的需求.

结论:

肠道微生物群调节代表了对MS的潜在治疗途径.
进一步的研究和精心设计的临床试验与更大的队列和延长后续是必不可少的.
未来的试验应考虑生命早期干预和长期监测,以捕捉复杂的系统间相互作用.

关键词:

肠大脑轴肠大脑轴炎症酶体 (inflammasomes) 是一种炎症酶体.神经炎症是一种神经炎症.氧化应急症是一种氧化应急症.

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