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Updated: Jul 21, 2025

Exogenous Administration of Microsomes-associated Alpha-synuclein Aggregates to Primary Neurons As a Powerful Cell Model of Fibrils Formation
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Exogenous Administration of Microsomes-associated Alpha-synuclein Aggregates to Primary Neurons As a Powerful Cell Model of Fibrils Formation

Published on: June 26, 2018

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氨基酸β1-42的寡合体诱导了加列-1S8的O-GlcNAcylation导致了微细胞迁移

Alazne Arrazola Sastre1,2, Miriam Luque Montoro1, Francisco Llavero1

  • 1Achucarro Basque Center for Neuroscience, Science Park of the UPV/EHU, Sede Building, 3rd Floor, Barrio de Sarriena s/n, 48940 Leioa, Spain.

Cells
|July 29, 2023
PubMed
概括

阿尔茨海默氏病 (AD) 涉及粉样β 1-42 (Aβ1-42) 寡合体,改变了微质细胞的功能. 这项研究揭示了Aβ1-42寡合体修改了Galactin-1 O-GlcNAcylation,影响了对大脑稳定至关重要的微细胞迁移.

关键词:
盖莱克1111盖莱克1谢林8OGlcNA化盖尔1S8AA的情况这是一种O-GlcNAcylation.其他 OGT 产品.粉样蛋白β142的寡合体微质细胞中的微质细胞移民 移民 迁移 迁移

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