低剂量的黑色素可以改善ADHD儿童的睡眠:一项开放试验
Ana Checa-Ros1,2, Antonio Muñoz-Hoyos3, Antonio Molina-Carballo3
1Grupo de Investigación en Enfermedades Cardiorrenales y Metabólicas, Departamento de Medicina y Cirugía, Facultad de Ciencias de la Salud, Universidad Cardenal Herrera-CEU, CEU Universities, Calle Santiago Ramón y Cajal s/n, Alfara del Patriarca, 46115 Valencia, Spain.
低剂量黑激素 (1毫克) 显著增加了儿童患有多动症多动症患者的总睡眠时间. 这种治疗显示出良好的安全性,这表明这种人群对睡眠有潜在的益处.
科学领域:
- 儿科睡眠医学 儿科睡眠医学
- 神经发育障碍 神经发育障碍
- 药理学 药理学是指药理学的学科.
背景情况:
- 有限的研究存在于低剂量黑激素对儿童睡眠的影响,特别是那些有多动症的儿童.
- 以前的研究主要集中在成年人群.
研究的目的:
- 调查1毫克黑激素 (aMT) 对被诊断患有多动症和接受甲基化物 (MPH) 治疗的儿科患者的睡眠模式的影响.
- 评估睡眠时间,睡眠开始延迟和睡眠效率的变化.
主要方法:
- 招募了患有延长释放MPH的ADHD儿童和青少年 (7-15岁) 的队列.
- 在七周内收集睡眠日记,随后进行了四周的治疗,在睡前服用1毫克aMT.
- 在干预之前和之后,用于七天睡眠评估的动图学.
主要成果:
- 27名儿科患者完成了这项研究.
- 在一个月的aMT治疗后,观察到总睡眠时间 (TST) 的统计显著增加 (从463分钟增加到485分钟;p <0.040).
- 没有注意到睡眠开始延迟 (SOL) 或睡眠效率的显著改善,报告了轻微的不良影响.
结论:
- 一毫克的黑激素有效地增加了接受精神兴奋剂治疗的ADHD儿童和青少年的总睡眠时间.
- 治疗表明了有利的耐受性概况.
- 建议进行进一步的安慰剂对照研究,以优化aMT的给药时间,以便在这个患者组中潜在地减少SOL.
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