相关实验视频
Updated: Jul 21, 2025

10:25
Isolation and Quantitative Evaluation of Brush Cells from Mouse Tracheas
Published on: June 12, 2019
7.3K
在裂口软 palates 的抗微生物和介质蛋白
Arina Deņisova1, Māra Pilmane1, Dzintra Kažoka1
1Institute of Anatomy and Anthropology, Riga Stradins University, Kronvalda Boulevard 9, LV-1010 Riga, Latvia.
Children (Basel, Switzerland)
|July 29, 2023
概括
这项研究发现,口腔裂组织中抗菌和抗炎细胞因子增加,这表明有补偿性免疫反应. 这些因素共同作用于口腔裂的发展.
科学领域:
- 免疫学 免疫学 免疫学
- 发展生物学 发展生物学
- 病理生理学 病理生理学
背景情况:
- 口腔裂是一种常见的先天性异常,其潜在机制仍在争论中.
- 保护性组织因子,如抗微生物和细胞因子在裂口病理生理学中的作用需要进一步研究.
研究的目的:
- 评估人类裂口口腔组织中特定抗微生物 (HBD-2,HBD-3,HBD-4,LL-37) 和细胞因子 (IL-10,CD-163) 的存在和分布.
- 探索裂口口腔组织中这些因素之间的潜在相关性.
主要方法:
- 软 palatal 组织样本是在皮整形手术过程中收集的.
- 免疫组织化学染色用于识别和量化HBD-2,HBD-3,HBD-4,LL-37,IL-10和CD-163阳性的细胞.
- 统计分析包括曼-惠特尼U测试和斯皮尔曼的等级相关系数.
主要成果:
- 在口腔裂口患者和对照者之间观察到HBD-2,IL-10 (上皮和结缔组织) 和HBD-4 (结缔组织) 的显著差异.
- 患者中HBD-3的存在量中度,对照组中稀少;LL-37在两组中都呈现出可变的存在.
- 在裂组织中研究的免疫因子之间发现了许多相关性,表明了协同作用的参与.
结论:
- 抗微生物 (HBD-2,HBD-4) 和抗炎细胞因子IL-10的高水平表明,免疫系统对裂口口腔组织变化的补偿反应.
- 这些局部防御因素之间的协同相互作用在产后发育和口腔裂的形态病原发生方面发挥着作用.
相关概念视频
Antimicrobial Proteins
1.0K
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
1.0K
Surface Membrane Barriers
1.2K
The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
1.2K
Defense Mechanism Against Infection
6.6K
Natural flora, body system defenses, and inflammation are natural barriers of the body against infectious agents regardless of previous exposure. Normal floras of the human body refer to the microbial population that colonizes the skin and mucous membranes.
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
6.6K
Gene Regulation in Microbial Communities: Quorum Sensing
40
Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
40
Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors
465
Peptic ulcer disease, commonly called PUD, represents a multifaceted condition characterized by disruptions in the lining of the gastrointestinal (GI) tract. Central to the protection of the gastrointestinal lining is the mucosal-bicarbonate barrier. This physiological defense mechanism is a formidable shield against the corrosive effects of gastric acid and pepsin secretion in the stomach. Its role is pivotal in maintaining the structural integrity of the stomach's inner lining.
465

