用于骨组织工程的三维支架
Harish Chinnasami1, Mohan Kumar Dey1, Ram Devireddy1
1Department of Mechanical Engineering, Louisiana State University, Baton Rouge, LA 70803, USA.
Bioengineering (Basel, Switzerland)
|July 29, 2023
概括
组织工程骨移植为骨缺陷的传统方法提供了一个有希望的替代方案. 本综述探讨了冷保存接种物的支架材料和制造技术,解决了当前的挑战和未来的方向.
科学领域:
- 生物材料科学 生物材料科学
- 组织工程是组织工程.
- 再生医学是一种再生医学.
背景情况:
- 目前用于主要骨缺陷的治疗方法,包括自体移植,面临着诸如捐赠部位病率和有限可用性等局限性.
- 组织工程骨移植,将支架与细胞结合起来,是克服这些局限性的潜在解决方案.
- 现有的骨移植材料包括陶和合成聚合物,每个都有特定的特性.
研究的目的:
- 对可冷保存的组织工程骨移植支架的材料和制造方法进行审查.
- 为了总结骨质合体模型和支架在体内应用的机械要求.
- 评估冷保存对脚手架完整性的影响,并讨论监管方面的问题.
主要方法:
- 审查传统的脚手架制造技术:溶剂造,气泡,电,和热诱导的相分离.
- 探索先进的制造方法:化沉积成型,立体石刻,选择性激光烧结,3D打印和生物打印.
- 对通过热诱导相分离制造的聚L-乳酸 (PLLA) 支架的冷保存效应的分析.
主要成果:
- 有各种各样的脚手架材料和制造技术可用于组织工程骨移植.
- 冷保存可以影响PLLA支架的结构和机械完整性.
- 特定的机械性能对于成功地在体内应用工程骨移植的关键.
结论:
- 组织工程骨移植具有治疗大型骨缺陷的巨大潜力.
- 了解材料特性和制造方法是开发有效的冷可保存支架的关键.
- 需要进一步的研究来优化冷保存协议,并满足临床翻译的监管要求.
相关概念视频
01:55Bone Structure
Within the skeletal system, the structure of a bone, or osseous tissue, can be exemplified in a long bone, like the femur, where there are two types of osseous tissue: cortical and cancellous.
01:23Bone as Supporting Connective Tissue
Bone tissue forms the internal skeleton of vertebrate animals, providing structure to the body.
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts— that give the...
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts— that give the...