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用于骨组织工程的三维支架

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  • 1Department of Mechanical Engineering, Louisiana State University, Baton Rouge, LA 70803, USA.

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概括
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组织工程骨移植为骨缺陷的传统方法提供了一个有希望的替代方案. 本综述探讨了冷保存接种物的支架材料和制造技术,解决了当前的挑战和未来的方向.

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科学领域:

  • 生物材料科学 生物材料科学
  • 组织工程是组织工程.
  • 再生医学是一种再生医学.

背景情况:

  • 目前用于主要骨缺陷的治疗方法,包括自体移植,面临着诸如捐赠部位病率和有限可用性等局限性.
  • 组织工程骨移植,将支架与细胞结合起来,是克服这些局限性的潜在解决方案.
  • 现有的骨移植材料包括陶和合成聚合物,每个都有特定的特性.

研究的目的:

  • 对可冷保存的组织工程骨移植支架的材料和制造方法进行审查.
  • 为了总结骨质合体模型和支架在体内应用的机械要求.
  • 评估冷保存对脚手架完整性的影响,并讨论监管方面的问题.

主要方法:

  • 审查传统的脚手架制造技术:溶剂造,气泡,电,和热诱导的相分离.
  • 探索先进的制造方法:化沉积成型,立体石刻,选择性激光烧结,3D打印和生物打印.
  • 对通过热诱导相分离制造的聚L-乳酸 (PLLA) 支架的冷保存效应的分析.

主要成果:

  • 有各种各样的脚手架材料和制造技术可用于组织工程骨移植.
  • 冷保存可以影响PLLA支架的结构和机械完整性.
  • 特定的机械性能对于成功地在体内应用工程骨移植的关键.

结论:

  • 组织工程骨移植具有治疗大型骨缺陷的巨大潜力.
  • 了解材料特性和制造方法是开发有效的冷可保存支架的关键.
  • 需要进一步的研究来优化冷保存协议,并满足临床翻译的监管要求.