循环-奥莱芬-共聚物 (COC) 基微通道的表面修饰,用于大规模工业生产滴滴微流体设备
Yefeng Guan1,2, Huiru Zhang2,3, Zhibin Yan4
1Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, Jinan University, Guangzhou 510632, China.
Bioengineering (Basel, Switzerland)
|July 29, 2023
概括
本研究介绍了环烯共聚合物 (COC) 微流体装置的表面修改,改善了滴滴生成稳定性. 疏水处理确保了尽管有压力波动,但持续的微量液滴产量.
科学领域:
- 聚合物科学 聚合物科学
- 微流体学 微流体学
- 表面化学 表面化学
背景情况:
- 环烯共聚合物 (COC) 是制造液滴微流体器件的关键热塑性材料.
- 表面的湿透性和压力稳定性显著影响COC装置的滴滴生成和均性.
- 现有的方法在大规模生产期间保持一致的滴滴特性时面临挑战.
研究的目的:
- 为COC微流体器件开发一种简单的表面修饰.
- 为了提高微量液滴生成的稳定性.
- 为应对工业制造中的表面湿透性和压力变化所带来的挑战.
主要方法:
- 对COC微通道的疏水表面修饰.
- 氧气等离子治疗,然后进行碳溶剂反应.
- 在波动压力下评估滴滴生成稳定性和均性.
主要成果:
- 经过修改的COC装置稳定地产生了微体积水滴,变化系数低.
- 尽管存在分散的相位压力波动,但仍能实现一致的滴滴生成.
- 疏水的表面修改证明了耐用性,持续长达四个月.
结论:
- 拟议的表面修改为COC微流体器件中稳定滴滴生成提供了强大的解决方案.
- 这种方法适用于微流体设备的大规模工业生产.
- 这些发现为聚合酶连锁反应和单细胞分析中的应用提供了指导.
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