高灵敏度C反应蛋白与缺血性中风亚急性阶段血压变化之间的关联
Chuanli Xu1, Zhiyong Fu2, Wei Wu3
1Department of Neurology, The Fourth Affiliated Hospital of China Medical University, Shenyang 110032, China.
Brain sciences
|July 29, 2023
概括
高灵敏度C反应蛋白 (hsCRP) 与缺血性中风的亚急期中短期血压变化 (BPV) 的增加有关. 较高的hsCRP水平与更大的血压波动相关,这表明它可能是用于监测中风恢复的潜在生物标志物.
科学领域:
- 神经学 神经学
- 心脏病学 心脏病学
- 炎症研究 炎症研究
背景情况:
- 血压变化 (BPV) 是影响缺血性中风后结果的复杂因素.
- 高敏感性C反应蛋白 (hsCRP) 是系统性炎症的标志物.
- 在亚急性中风阶段hsCRP和短期BPV之间的关系需要进一步阐明.
研究的目的:
- 调查循环hsCRP水平与短期BPV之间的关联.
- 确定hsCRP是否是缺血性中风亚急性阶段血压波动增加的预测因素.
主要方法:
- 观察性研究包括325名急性缺血性中风患者.
- 24小时的门诊血压监测 (ABPM) 在中风发作后4-10天进行.
- 用于分析hsCRP和BPV指标 (SD,CV,ARV) 之间的关系的多变量线性回归模型.
主要成果:
- 患有hsCRP水平≥2 mg/L的患者表现出更高的24小时内和腹血压变化.
- 在调整了混因素后,这种关联仍然存在.
- 在hsCRP水平和BPV之间观察到剂量反应关系,较高的hsCRP四分位数显示出更大的变化.
- 升高的hsCRP也与较高的平均静缩血压有关,但不是平均静缩血压.
结论:
- 循环hsCRP与缺血性中风的亚急性阶段的短期血压变化有关,这取决于剂量.
- 较高的hsCRP水平可能表明中风患者的血压波动趋势较大.
- hsCRP可以作为监测BPV和指导中风后护理管理策略的潜在生物标志物.
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