时间变化揭示了人类新皮层的顺序发展和唐氏综合症大脑的扭曲发育时间
Yuqiu Zhou1, Li Tao1, Ying Zhu1
1State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Institutes of Brain Science and Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai 200032, China.
Brain sciences
|July 29, 2023
概括
这项研究介绍了TempShift,这是一个R包,用于分析开发期间的基因表达时间. 它揭示了新皮层区域和唐氏综合征大脑的独特发育模式,突出了基因调节的时间变化.
科学领域:
- 发育生物学是发展生物学.
- 神经科学是一个神经科学.
- 生物信息学是一种生物信息学.
背景情况:
- 发育调节在组织和个体之间有所不同,在疾病中经常发生变化.
- 新皮层区域的发育和唐氏综合征 (DS) 脑部变化缺乏明确的时间调节理解.
- 在发育过程中基因表达的变化可以反映出改变的细胞组成或时间变化.
研究的目的:
- 开发一种计算工具,以区分基因表达轨迹形状的变化和时间变化.
- 应用此工具来分析新皮层发育和DS大脑中的基因表达动态.
主要方法:
- 开发了一个名为TempShift的R包.
- TempShift区分时间转移和基因表达轨迹的不同形状 (DiffShape).
- 多个基因表达轨迹之间的估计时间差异.
主要成果:
- 识别了11个新皮层区域的顺序基因表达,表明有序的突触形成和轴突引导.
- 在新皮层内重建的内部神经元迁移路径.
- 与对照人群相比,在DS大脑中观察到微质细胞增加,神经元迁移缩短,神经元突变/髓化延迟.
结论:
- TempShift有效地区分时间基因表达转移与形状变化.
- 该工具提供了对新皮层区域和DS中的发育时间的洞察.
- TempShift有可能研究各种生物过程中的基因表达动态.
相关概念视频
Meiosis vs. Mitosis
57.1K
Cell division is necessary for growth and reproduction in organisms. Mitosis aids cell growth and development by dividing somatic cells. In contrast, meiosis causes the division of germ cells and plays an essential role in sexual reproduction. Due to their unique functional requirements, mitosis and meiosis differ from each other in multiple aspects.
Before the start of mitosis and meiosis I, the cell synthesizes DNA, resulting in two homologous copies of each chromosome. DNA synthesis is...
Before the start of mitosis and meiosis I, the cell synthesizes DNA, resulting in two homologous copies of each chromosome. DNA synthesis is...
57.1K
Three Developmental Domains
180
Human development is typically examined across three main domains: physical, cognitive, and socio-emotional. These domains represent the significant areas of change and continuity throughout the lifespan, from infancy to late adulthood.
Physical Development
Physical processes, also known as maturation, encompass the biological changes that occur across an individual's life. These changes begin with genetic inheritance and continue through various stages, including growth in height and...
Physical Development
Physical processes, also known as maturation, encompass the biological changes that occur across an individual's life. These changes begin with genetic inheritance and continue through various stages, including growth in height and...
180
Neurulation
42.1K
Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...
42.1K


