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Updated: Jul 21, 2025

Identification of Circular RNAs using RNA Sequencing

Identification of Circular RNAs using RNA Sequencing

Published on: November 14, 2019

循环RNA及其在男性不孕症中的作用:系统性审查

Maria-Anna Kyrgiafini¹, Zissis Mamuris¹

¹Laboratory of Genetics, Comparative and Evolutionary Biology, Department of Biochemistry and Biotechnology, University of Thessaly, Viopolis Mezourlo, 41500 Larissa, Greece.

|July 29, 2023

概括

循环RNAs (circRNAs) 越来越多地与男性不孕症有关. 本次审查强调了它们的失调和作为查生物标志物的潜力,尽管对于特定的不孕不育类型需要更多的研究.

科学领域:

生殖生物学生殖生物学
遗传学遗传学是一个
分子生物学分子生物学

背景情况:

男性不孕症是一个日益严重的全球健康问题.
非编码RNAs (ncRNAs),特别是循环RNAs (circRNAs),正在成为男性生殖健康的重要因素.
目前对circRNAs在男性不孕症中的特定作用的理解仍然有限.

研究的目的:

系统地审查男性不孕症中circRNAs的差异表达.
确定有潜力作为男性不孕症的诊断或预后生物标志物的circRNAs.
评估有关circRNAs和男性不孕症的当前知识格局.

主要方法:

根据PRISMA指南进行了系统审查.
在PubMed和Web of Science数据库中进行了搜索,截至2023年1月11日.
包括关注人类参与者的研究,circRNAs与男性不孕症之间的实验关联,以及报告的差异表达的circRNAs.

主要成果:

13项研究符合纳入标准,揭示了男性不孕症中circRNAs的广泛放松调节.
circRNAs及其与microRNAs (miRNAs) 的相互作用显著影响细胞过程和与生育相关的途径.
circRNAs在不孕男性中显示出前精子检索查的生物标志物.

结论:

circRNAs在男性不孕症的病理生理学中起着显著的作用.
circRNAs代表了男性不孕症查的潜在新生物标志物.
进一步的研究是必不可少的,以阐明circRNAs的精确机制,并验证它们在各种不孕不育亚型中的生物标志物实用性,特别是超越亚精子症.

关键词:

亚精子缺血症 (Azoospermia) 是一种生物标志物生物标志物圆形的RNAs是圆形的RNAs.男人的不孕不育症.

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