在黑色素瘤和非黑色素瘤皮肤癌中全身光保护
Mariafrancesca Hyeraci1,2, Elena Sofia Papanikolau1, Marta Grimaldi3
1IDI-IRCCS, Dermatological Research Hospital, Via dei Monti di Creta 104, 00167 Rome, Italy.
Biomolecules
|July 29, 2023
概括
使用尼古丁胺胺等口服化合物的系统光保护可以帮助预防非黑色素瘤皮肤癌 (NMSCs). 然而,目前的选择尚未被证明对恶性黑色素瘤 (MM) 有效.
科学领域:
- 皮肤病学和瘤学
- 摄影生物学 摄影生物学
- 预防医学 预防医学
背景情况:
- 非黑色素瘤皮肤癌 (NMSCs),包括基底细胞癌 (BCC) 和状细胞癌 (SCC),在白人中很普遍,如果不治疗,可以转移.
- 恶性黑色素瘤 (MM),虽然不太常见,但造成更大的死亡风险.
- 紫外线 (UV) 辐射是主要的危险因素,需要有效的皮肤癌预防策略.
研究的目的:
- 审查关于全身光保护性化合物的临床和临床前数据.
- 专注于它们的紫外线保护作用背后的机制.
- 评估它们在预防非黑色素瘤皮肤癌 (NMSCs) 和恶性黑色素瘤 (MM) 的有效性.
主要方法:
- 对系统性光保护剂的临床和临床前研究的文献综述.
- 分析科学数据,重点关注抗氧化,抗炎和免疫调节机制.
- 审查支持将化合物纳入国际指南的证据.
主要成果:
- 尼古丁胺和视网类药物是为数不多的化合物之一,在预防NMSC方面已经证明了临床疗效.
- 系统性光保护包括口服具有抗氧化,抗炎或免疫调节性质的分子.
- 目前,没有系统性光保护剂在预防恶性黑色素瘤 (MM) 中被证明有效.
结论:
- 系统性光保护为NMSC预防提供了一个有前途的途径,尼古丁胺是其中的一个关键例子.
- 需要进一步的研究,以开发有效的系统性光保护策略来预防恶性黑色素瘤 (MM).
- 了解作用机制对于识别和开发新型光保护剂至关重要.
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