微生物群和IL-33/31轴的联系:在亚托匹性皮肤炎和牛皮的治疗影响和前景
Laura Bonzano1, Francesco Borgia2, Rossella Casella3
1Dermatology Unit, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, 42122 Reggio Emilia, Italy.
Biomolecules
|July 29, 2023
概括
微生物组失调症可能会引发在亚托皮性皮炎 (AD) 和牛皮 (PsO) 中出现的免疫失衡,导致与IL-33 (IL-33) 和IL-31相关的炎症. 这表明,针对微生物组的疗法可以治疗这些慢性皮肤疾病.
科学领域:
- 免疫学 免疫学 免疫学
- 皮肤病学 皮肤病学
- 微生物学 微生物学
- 过敏学 过敏学
背景情况:
- 亚托皮炎 (AD) 和牛皮 (PsO) 是常见的,繁重的性皮肤疾病,其特点是微生物组失调和改变的细胞因子概况.
- 介素-33 (IL-33) 和IL-31是关键的细胞因子,与AD和PsO等慢性炎症性皮肤疾病的发病和维持有关.
- 在AD和PsO中,dysbiosis和免疫失调之间的相互作用是复杂的,关于主要致病因子的争论正在进行中.
研究的目的:
- 调查微生物组失调是AD和PsO中观察到的IL-33/IL-31失调的发起因素的假设.
- 审查现有的关于微生物组,IL-33和IL-31在这些皮肤疾病的发病过程中的作用的文献.
主要方法:
- 使用PubMed数据库进行了一项文献审查.
- 评估了免疫学,皮肤学,微生物学和过敏学领域的文章.
主要成果:
- 该综述支持这样一个假设:在AD和PsO中,dysbiosis在IL-33/IL-31轴失调之前并可能驱动IL-33/IL-31轴失调.
- 有证据表明,微生物失衡与这些疾病所涉及的炎症途径之间存在重要联系.
结论:
- 微生物组失调被认为是IL-33/IL-31失调的潜在根本原因,有助于亚托皮炎和牛皮.
- 针对微生物组,IL-31和IL-33的治疗策略正在开发中,以管理这些皮肤性疾病.
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