为血管病变和血管生成而衍生出的细胞外囊:治疗应用和优化
Ying Zhu1,2, Zhao-Fu Liao1, Miao-Hua Mo1
1Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan 523808, China.
Biomolecules
|July 29, 2023
概括
介质细胞流体细胞衍生的细胞外囊泡 (MSC-EVs) 是血管平衡的关键调节者,促进血管生成和治疗各种血管疾病. 优化MSC-EV传递和生物活性对于临床转换至关重要.
科学领域:
- 细胞生物学 细胞生物学
- 再生医学是一种再生医学.
- 血管生物学 血管生物学
背景情况:
- 细胞外囊泡 (EVs) 对于细胞间通信至关重要.
- 介酶体 stromal 细胞衍生的 EVs (MSC-EVs) 在再生医学和治疗缺血性疾病方面显示出治疗的前景.
- MSC-EVs在各种血管病变中表现出有益的影响.
研究的目的:
- 阐明MSC-EVs在各种血管病变和血管生成中的功能作用.
- 探索MSC-EV如何有助于维持血管系统恒温.
- 讨论优化MSC-EV治疗应用的战略.
主要方法:
- 对血管恒温和血管生成中的MSC-EVs现有文献的综述.
- 在不同的血管病变中分析MSC-EV的机制.
- 讨论加强MSC-EVs生物活性,产量,交付和受控释放的战略.
主要成果:
- MSC-EV加速血管生成,对各种血管疾病产生有益影响.
- MSC-EV在调节血管平衡中发挥着重要作用.
- 修改后的MSC-EV和基于生物材料的输送系统可以增强治疗潜力.
结论:
- 在血管疾病中,MSC-EV具有显著的治疗潜力.
- 优化MSC-EVs的生物活性,产量和输送对于临床转化至关重要.
- 克服MSC-EV生产和交付方面的挑战是广泛临床应用的关键.
相关概念视频
01:19Mesenchymal Stem Cells
4.8K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
4.8K
01:24Regulation of Angiogenesis and Blood Supply
2.6K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.6K
01:21Stem Cell Therapy for Tissue Regeneration
4.1K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.1K