生物衰老对不同树脂复合材料机械性能和微生物行为的影响
Yuke Shou1, Lanzhi Deng1, Xiaoyu Huang1
1State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Biomolecules
|July 29, 2023
概括
这项研究发现,在30天的唾液生物膜衰老后,各种填充剂类型的树脂复合材料保持了稳定的机械性能和微生物行为. 不同的填充复合材料在具有挑战性的口腔环境中表现出弹性.
科学领域:
- 牙科材料科学 牙科材料科学
- 生物材料工程 生物材料工程
- 微生物学 微生物学
背景情况:
- 由于生物衰老,口腔环境对树脂复合材料的性能构成挑战.
- 了解树脂复合材料中的不同填充剂类型如何承受生物老化对于长期临床成功至关重要.
研究的目的:
- 研究唾液生物膜诱导生物衰老对不同填充剂类型 (微混合体,纳米混合体,纳米填充,纳米流动) 的树脂复合材料的机械性能和微生物行为的影响.
主要方法:
- 用唾液生物膜对复合样本进行生物衰老30天.
- 评估表面形态,粗度,机械性能 (弹性模量,屈曲强度,维克斯硬度) 和美学性能.
- 使用唾液生物膜模型进行微生物行为的体外评估 (代谢活动,乳酸生产,活/死染色).
- 在志愿者佩戴的复合板上生物膜形成的现场评估,使用16S rRNA测序.
主要成果:
- 在生物衰老后,没有观察到表面粗度,水吸收或溶解度的显著变化.
- 弹性模量保持稳定;除了纳米浮性复合材料外,大多数组的屈曲强度下降. 维克斯硬度是稳定的,除了纳米填充复合材料.
- 实验室生物膜代谢活性和乳酸产量略有增加,但不显著. 在现场,生物膜的多样性减少了,但基因层的组成仍然相似.
结论:
- 具有不同填充剂类型的树脂复合材料在经过30天的生物衰老后表现出相对稳定的机械性能和不妥协的微生物行为.
- 材料的选择可以基于临床需求,但需要长期研究才能充分确定长期的机械和微生物特性.
相关概念视频
01:19The Effect of Aging on Tissues
2.2K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.2K
01:29Bone Disorders
3.7K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.7K
01:29Biofilms
56
Biofilms are complex communities of microorganisms encased in a self-produced extracellular polysaccharide matrix attached to surfaces. These microbial consortia can include single or multiple species, providing enhanced survival benefits by forming organized, multilayered structures.The formation of biofilms occurs through four key stages: attachment, colonization, development, and dispersal.During attachment, free-swimming planktonic cells adhere to a surface, often facilitated by...
56
01:26Aging
86
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
86