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对活体中子捕获疗法的替代成像方法的研究

Dayron Ramos López^1,2, Gabriella Maria Incoronata Pugliese^1,2, Giuseppe Iaselli^1,2

¹Dipartimento Interateneo di Fisica, Università degli Studi di Bari Aldo Moro, 70125 Bari, Italy.

|July 29, 2023

概括

这项研究探讨了中子捕获疗法 (BNCT) 剂量测量和瘤监测的成像技术. 使用MLEM和CNN方法的康普顿摄像头成像显示,在BNCT期间跟踪剂量和瘤具有前途.

科学领域:

医学物理医学物理
辐射疗法辐射疗法
核医学是一种核医学.

背景情况:

中子捕获疗法 (BNCT) 提供选择性癌症治疗.
准确的体内剂量测量对于有效的BNCT输送至关重要.
康普顿相机是BNCT成像应用的新兴工具.

研究的目的:

评估在BNCT中进行体内剂量测量和瘤监测的成像方法.
评估最大概率预期最大化 (MLEM) 和卷积神经网络 (CNN) 对于BNCT成像的性能.
分析影响图像重建和准确性的临床因素.

主要方法:

利用蒙特卡洛模拟来生成用于成像分析的专用数据集.
应用MLEM代重建用于剂量计断层扫描.
研究了瘤监测的形态过和基于CNN的方法.
分析了临床方面,包括度比率和探测器效应.

主要成果:

MLEM证明了监测剂量分配的可行性.
基于CNN的瘤监测产生了有希望的结果,表明临床应用的潜力.
分析显示了对度和探测器定位的依赖.

结论:

康普顿摄像机成像与MLEM和CNN相结合显示了BNCT剂量测量和瘤监测的潜力.
进一步开发,特别是扩大CNN培训数据,可以提高临床效用.
该研究提供了对优化BNCT成像以改善治疗结果的见解.

关键词:

在 BNCT 上,你会发现.康普顿摄像机康普顿摄像机 MLEM MLEM的意思是蒙特卡罗的蒙特卡罗是一个非常好的城市.深度学习是一种深度学习.影像成像技术影像成像技术

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