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软组织肉 Sarcoma 模仿黑色素瘤:一个系统的审查

Fortunato Cassalia¹, Francesco Cavallin², Andrea Danese³

¹Unit of Dermatology, Department of Medicine, University of Padua, 35121 Padua, Italy.

|July 29, 2023

概括

瘤可以模仿黑色素瘤,使诊断复杂化. 本综述强调了被误诊为黑色素瘤的病例,强调需要进一步调查,特别是用于准确诊断肉瘤的EWSR1转位分析.

科学领域:

在瘤学瘤学.
病理学病理学病理学
遗传学是一个遗传学.

背景情况:

瘤和恶性黑色素瘤共享重叠的形态和免疫组织化学特征.
区分这些新生体带来了诊断挑战.

研究的目的:

系统地审查最初被误诊为黑色素瘤的肉瘤病例.
识别关键的诊断标记和遗传改变.

主要方法:

在MEDLINE/Pubmed,EMBASE和SCOPUS数据库中进行全面的文献搜索,截至2023年3月.
根据PRISMA指南,包括案例系列和案例报告.

主要成果:

从23个病例报告和4个病例系列中分析了34名患者.
通常错误识别的免疫组织化学标志物包括S100 (69%) 和HMB45 (63%).
在94%的测试患者中,EWSR1转位呈阳性,清晰细胞肉瘤是常见的最终诊断.

结论:

最初被诊断为黑色素瘤的非典型病变可能代表肉瘤.
考虑第二次诊断意见和对EWSR1转位的调查对于准确诊断至关重要.

关键词:

黑色素瘤是一种黑色素瘤.模仿模仿的模仿肉瘤肉瘤是一种肉瘤.

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