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双边和单边多焦点在乳头甲状腺癌的临床含义:一种倾向性得分匹配研究

Youngmin Kim¹, Solji An¹, Joonseon Park¹

¹Department of Surgery, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.

|July 29, 2023

概括

与双边PTC相比,单侧多焦点乳头甲状腺癌 (PTC) 显示出更高的复发风险和较差的无病生存率,特别是在倾向性得分匹配后. 对于单方面病例来说,早期发现和密切跟踪至关重要.

科学领域:

内分泌学在内分泌学.
在瘤学瘤学.
手术病理学手术病理学

背景情况:

多焦点是乳头甲状腺癌 (PTC) 的常见特征,通常与侵袭性疾病和更差的预后有关.
了解多焦点PTC中癌症横向性的影响对于治疗规划和预测结果至关重要.

研究的目的:

为了比较双边和单边多焦点PTC之间的临床病理特征和长期瘤结果.
根据多焦点PTC的癌症横向性来调查复发风险和无病生存期 (DFS).

主要方法:

对1745名经过甲状腺手术的多焦点PTC患者的回顾性审查.
基于癌症横向性的临床病理特征和复发率的比较.
倾向性得分匹配 (PSM) 应用于357名接受全甲状腺切除术的患者,以分析复发风险和DFS.

主要成果:

在PSM之前,双边和单边多焦点PTC组之间没有观察到复发率的显著差异.
在PSM之后,单侧多焦点与更高的复发风险和更差的DFS显著相关.
考克斯回归分析表明,癌症侧面性最初不是DFS的预测因素,但PSM后的Kaplan-Meier分析显示单侧多焦点PTC的DFS较差.

结论:

与双边多焦点PTC相比,单边多焦点PTC,特别是通过PSM考虑混因素后,呈现出更高的复发风险和更差的无病生存率.
综合性手术前评估以检测多焦点是最优的手术规划必不可少的.
建议对单边多焦点PTC进行短期术后随访,以监测复发情况.

关键词:

两国之间的双边关系.没有疾病的生存率.皮囊甲状腺癌是甲状腺癌.倾向性得分匹配的比分匹配单方面的多焦点性.

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