微RNA作为质瘤和初级中枢神经系统淋巴瘤之间的诊断标记:系统性审查
Mohammad Amin Dabbagh Ohadi1,2, Mir Sajjad Aleyasin3, Reza Samiee3
1Department of Pediatric Neurological Surgery, Children's Medical Center, Tehran University of Medical Sciences, Tehran 1419733151, Iran.
Cancers
|July 29, 2023
概括
液体活检中的特定微RNA (miRs) 显示出明显的模式,使质瘤与初级中枢神经系统淋巴瘤 (PCNSL) 区别开来. 这些循环生物标志物有可能提高神经瘤学中的诊断准确性.
科学领域:
- 神经瘤学神经瘤学
- 分子诊断学 分子诊断学
- 生物标志物发现发现
背景情况:
- 将结质瘤与初级中枢神经系统淋巴瘤 (PCNSL) 区分开来,带来了诊断上的挑战.
- 像MRI和活检这样的当前方法在有效性上有局限性.
- 液体活检提供了一种非侵入性的方法来检测循环中的生物标志物,如微RNA (miRs).
研究的目的:
- 审查特定miRs在诊断和区分质瘤与PCNSL中的作用.
- 为了确定这些脑瘤的诊断潜力,循环的miRs.
主要方法:
- 在主要的科学数据库 (PubMed,Scopus,Web of Science,Embase) 进行系统的文献搜索.
- 专注于研究研究质瘤和PCNSL诊断液体活检的研究.
- 对失调的miRs及其患者群体表达水平的分析.
主要成果:
- 十六个失调的miRs显示了质瘤和PCNSL之间的差异表达.
- 在PCNSL中,miR-21水平最高,其次是质瘤.
- 在质瘤中,miR-16和miR-205的含量最低,而在两种瘤类型中,miR-15b和miR-301的含量较高.
- 与对照组相比,miR-711在质瘤 (包括质母细胞瘤) 中升高,在PCNSL中下调.
结论:
- 特定的循环miRs表现出独特的表达模式,可以帮助区分质瘤,特别是质母细胞瘤,从PCNSL.
- 这些miR有望成为改善诊断歧视的非侵入性液体生物标志物.
关键词:
生物标志物 生物标志物诊断 诊断 诊断 诊断 诊断 诊断歧视是一种歧视.质母细胞瘤 (glioblastoma) 是一种质瘤 质瘤 是一种液体活检活检液体活检在 miR-15b 中使用.据报道,米R-16的发射器已经被发现.在 miR-205 之前,它是 miR-205.这就是miR-21的原因.这就是为什么miR-301是MIR-301.在 miR-71111 里.这是一个微型RNA.主要的中枢神经系统淋巴瘤更多相关视频
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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
