尿癌的免疫疗法:在达到反应时停止,在疾病进展时重新开始
Youssra Salhi1, Ronald De Wit1, Debbie Robbrecht1
1Department of Medical Oncology, Erasmus MC Cancer Institute, Dr. Watermolenplein 40, 3015 GD Rotterdam, The Netherlands.
Cancers
|July 29, 2023
概括
对于响应像布罗利祖马布这样的PD-(L) 1抑制剂的尿道癌患者来说,更短的治疗持续时间是有效的. 如果需要,早期停止治疗和重新治疗可以保持良好的结果,改善生活质量.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 尿癌研究 尿癌研究
背景情况:
- 在尿路癌 (UC) 中,PD-(L) 1 抑制剂的最佳治疗持续时间缺乏共识.
- 目前的实践往往涉及长达2年的治疗,即使对于具有持久反应的患者.
- 延长治疗时间的必要性和对生活质量的影响需要进行调查.
研究的目的:
- 为了评估本地晚期或转移性UC患者的pembrolizumab治疗持续时间.
- 评估停止治疗的原因,随后的治疗方法和生存结果.
- 确定早期停药和按需重新治疗是否是 UC 患者对免疫治疗有反应的可行策略.
主要方法:
- 从荷兰接受布罗利祖马布治疗的UC患者回顾性数据收集 (2017年9月至2019年12月).
- 对治疗持续时间,中止原因和随访生存数据的分析.
- 包括接受一线或二线 pembrolizumab 治疗的患者.
主要成果:
- 分析了74名患者的数据;85%的患者接受了≤12个月的 pembrolizumab.
- 只有3%的患者 (2/74) 接受了12-24个月的治疗,11%的患者 (8/74) 完成了24个月的治疗.
- 在≤12个月治疗后部分/完全响应的患者和24个月治疗的患者中观察到100%的存活率;三名患者在进展后再次接受治疗.
结论:
- 在UC患者实现部分或完全反应时,早期停止使用 pembrolizumab 是一个合理的策略.
- 如果疾病进展,重新开始治疗可以保持良好的结果.
- 进一步的研究是有必要的,以优化治疗时间的回应UC患者.
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