转换阿片类药物在晚期癌症疼痛中的有效性:一项前性观察性队列研究
Aaron K Wong1,2,3, Andrew A Somogyi4, Justin Rubio5
1Department of Palliative Care, Peter MacCallum Cancer Centre, Melbourne 3052, Australia.
Cancers
|July 29, 2023
概括
转换阿片类药物有效地减少了晚期癌症患者的疼痛和心理痛苦. 这种常见的做法还在一周内显著减少了不良影响,改善了症状控制.
科学领域:
- 抚慰性护理是一种缓解性护理.
- 在瘤学瘤学.
- 疼痛管理 疼痛管理
背景情况:
- 转换阿片类药物经常用于晚期癌症疼痛管理.
- 支持其在改善止痛和减少不良影响方面的有效性证据有限.
- 这项研究解决了对该人口中阿片类药物转换的可靠数据的需求.
研究的目的:
- 为了评估阿片类药物切换在晚期癌症患者的有效性.
- 评估疼痛强度的变化,突破性疼痛和心理困扰.
- 为了比较阿片类药物转换和继续当前阿片类药物治疗之间的不良影响的发生率.
主要方法:
- 一个多中心前性队列研究.
- 患者被分为阿片类药物切换组和对照组 (正在进行的阿片类药物治疗).
- 关于疼痛,不良反应和痛苦的数据在基线和七天后收集.
主要成果:
- 转换阿片类药物显著降低了疼痛评分 (最差,平均,现在) 和不受控制的突破性疼痛 (p < 0.05,p = 0.008).
- 心理痛苦在转换组显著下降 (48%至16%,p < 0.005).
- 切换组报告了7个中度至重度不良反应的≥25%的减少,与对照组中的1个相比.
结论:
- 转换阿片类药物是一种有效的策略,用于管理晚期癌症的疼痛,副作用和心理痛苦.
- 在一周内,阿片类药物切换为大多数患者实现了令人满意的症状控制.
- 这种做法为改善癌症息护理中的生活质量提供了有价值的选择.
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