对于没有接受手术的脉冲性癌症患者的治疗模式和结果
Benjin D Facer1, Jordan M Cloyd2, Ashish Manne3
1Department of Radiation Oncology, The Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA.
Cancers
|July 29, 2023
概括
对于无法接受手术的囊腺癌患者,单独的化疗和化疗加终极辐射疗法显示了类似的生存结果. 大多数患者没有接受治疗,这凸显了局部疾病的护理差距.
科学领域:
- 在瘤学瘤学.
- 胃肠道瘤学 胃肠道瘤学
- 临床研究 临床研究
背景情况:
- 手术切除对于囊腺癌 (AC) 是标准的,但许多患者是不合格的.
- 对于局部AC的最佳非操作管理缺乏强有力的证据.
- 这项研究解决了非手术AC候选人的治疗差距.
研究的目的:
- 为了比较局部,非转移性囊腺癌患者的整体存活率 (OS),仅用化疗治疗,而不是化疗加终性辐射治疗.
- 分析不接受手术的AC患者的治疗模式.
主要方法:
- 国家癌症数据库 (2004-2017) 的回顾性审查.
- 包括没有手术干预的非转移性AC患者.
- 卡普兰-梅尔分析和日志等级测试用于跨治疗组的生存比较 (没有治疗,PRT,CT,CT+PRT,DRT,CT+DRT).
主要成果:
- 在2176名符合条件的患者中,71.2%没有接受治疗.
- 一年后的OS在35.1% (仅PRT) 到59.4% (CT + DRT) 之间.
- 单独使用化疗和使用化疗加绝对辐射疗法 (HR 0.87,p=0.87) 之间在一年的生存期没有显著差异.
结论:
- 大多数非手术性AC患者没有接受治疗.
- 化疗加上终极辐射治疗与局部AC单独化疗相比,并没有显著改善存活率.
- 需要进一步的研究,以优化非手术治疗策略,以治疗囊腺癌.
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