硫化改善了与SARS-CoV-2相关的肺内皮屏障破坏
Olivier Escaffre1,2, Peter Szaniszlo3, Gabor Törő3
1Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Biomedicines
|July 29, 2023
概括
硫化 (H2S) 释放的化合物,如GYY4137,在保护肺内皮细胞免受COVID-19损伤方面表现有希望. 这项研究证明了H2S供体.
科学领域:
- 肺部医学 肺部医学
- 内皮细胞生物学 内皮细胞生物学
- COVID-19的病理生理学
背景情况:
- 肺微血管内皮损伤是COVID-19的一个关键因素.
- 硫化 (H2S) 已在各种病理条件下表现出有益作用.
- 以前的研究表明,H2S在COVID-19治疗中具有治疗潜力.
研究的目的:
- 为了研究H2S捐赠者GYY4137对肺内皮细胞屏障功能的保护作用.
- 评估COVID-19患者血和无活化的SARS-CoV-2对内皮屏障完整性的影响.
- 为了将血细胞因子/化学因子概况,内皮透气性和疾病严重程度相关联.
主要方法:
- 使用了体外肺内皮细胞单层模型.
- 挑战细胞与COVID-19患者的血和非活化的SARS-CoV-2病毒.
- 使用电阻测量了内皮屏障透性的实时变化.
主要成果:
- GYY4137治疗显著降低了内皮屏障的透性,当挑战患者的血时.
- GYY4137完全逆转了因无活化的SARS-CoV-2引起的内皮屏障破坏.
- 疾病严重程度与血细胞因子/化学因子概况相关,但在本试验中没有与屏障透性相关.
结论:
- 释放H2S的化合物,如GYY4137,可以减轻SARS-CoV-2引起的肺内皮屏障破坏.
- 这些发现支持H2S捐赠者的治疗潜力,用于管理COVID-19并发症.
- 需要进一步的研究来探索针对COVID-19的基于H2S的疗法.
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