肠道微生物群和肝移植:排斥背后的免疫机制
Ludovico Abenavoli1, Giuseppe Guido Maria Scarlata1, Maria Rosaria Paravati1
1Department of Health Sciences, University "Magna Graecia", 88100 Catanzaro, Italy.
Biomedicines
|July 29, 2023
概括
肝移植 (LT) 后肠道微生物组合的变化可能会影响移植的拒绝. 监测这些微生物转移对于预防排斥和改善移植成功至关重要.
科学领域:
- 胃肠病学和肝病学
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
背景情况:
- 肝移植 (LT) 是对末期肝病,肝硬化和肝细胞癌 (HCC) 的关键治疗方法.
- 移植体排斥,发生在3-25%的LT病例中,构成重大威胁,可能导致移植体丢失或患者死亡.
- 肠肝轴突出了肠道微生物群和肝脏健康之间的复杂关系,包括免疫调节.
研究的目的:
- 审查肝移植前后肠道微生物群组成的变化.
- 探索潜在的免疫机制,将肠道失调与LT后的急性移植拒绝联系起来.
- 强调监测肠道微生物群对于LT成功和预防排斥的重要性.
主要方法:
- 对评估肝硬化患者和肝移植后肠道微生物群的研究进行文献综述.
- 对肠肝轴和免疫反应调节的现有研究进行分析.
- 假设免疫路径将肠道失调与肝移植排斥联系起来.
主要成果:
- 在接受肝移植的患者中,肠道微生物群的组成会发生显著的变化.
- 肠道失生症与改变的免疫反应有关,这可能导致急性移植排斥.
- 有限的研究直接评估了前和后LT肠道微生物群对排斥发病率的影响.
结论:
- 肠道微生物群的变化在肝移植之前和之后都很明显.
- 肠道功能失调可能是肝移植排斥的可修改风险因素.
- 监测肠道微生物群组成对于评估LT结果和实施预防策略至关重要.
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