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基于细胞透的宏分子药物的输送:开发,策略和进展

Zhe Sun1, Jinhai Huang1, Zvi Fishelson2

  • 1School of Life Sciences, Tianjin University, Tianjin 300072, China.

Biomedicines
|July 29, 2023
PubMed
概括

细胞透 (CPPs) 提供了卓越的药物递送性能. 本综述详细介绍了CPP开发,输送系统,吸收机制和宏分子药物的优化策略,强调了成功临床应用的条件.

关键词:
生物屏障是一种生物屏障.细胞透的.细胞吸收机制的机制大分子药物输送.优化了战略,优化了战略.

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Cellular Membranes and Drug Transport

Drugs must traverse multiple biological barriers, such as multi-layered skin, single-layered intestinal epithelium, and the plasma membrane, to reach their target sites within the body. The plasma membrane, a highly structured composite of phospholipids, carbohydrates, and proteins, is the cell's protective boundary, facilitating selective substance exchange.
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Mechanisms of Drug Absorption: Paracellular, Transcellular, and Vesicular Transport

Drugs need to permeate cell membranes to reach their target sites after administration. Orally administered drugs must transcend intestinal epithelial membrane barriers to infiltrate the systemic circulation. Drugs with a molecular weight of less than 500 Daltons diffuse through gaps between neighboring cells, called paracellular pathways.
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Drug Delivery: Overview

The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
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Pore Transport and Ion-Pair Transport01:17

Pore Transport and Ion-Pair Transport

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Pore transport, also known as convective transport, is a process where small molecules like urea, water, and sugars rapidly cross cell membranes as though there were channels or pores in the membrane. Although direct microscopic evidence is limited  but the concept of pores or channels is widely accepted based on physiological evidence. Despite the lack of direct...
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