在生物能量转导中转换轮
Yanfei Zhang1, Hans V Westerhoff1,2,3,4
1Synthetic Systems Biology and Nuclear Organization, Swammerdam Institute for Life Sciences, University of Amsterdam, 1098 XH Amsterdam, The Netherlands.
Entropy (Basel, Switzerland)
|July 29, 2023
概括
在恶劣的条件下,生物系统可以"转换轮"以优化能源使用. 这包括切换到具有较低ATP输出的途径,增加整体增长和性能.
科学领域:
- 非平衡的热力学.
- 生物物理学的生物物理.
- 代谢调节 代谢调节 代谢调节
背景情况:
- 无生命机器使用变速器在不利条件下管理能量输出.
- 这个概念在生物系统中被低估了.
- 生物依靠能量转导来完成诸如微生物生长等过程.
研究的目的:
- 扩展非平衡热力学原理以解释生物变速.
- 为了确定生物轮转换的潜在机制.
- 为了研究变速器如何影响细胞性能和生长.
主要方法:
- 非平衡热力学原理的理论延伸.
- 代谢途径和ATP合成流量的分析.
- 在不同的能量条件下对细胞生长的建模.
主要成果:
- 生物轮转换与改变合的程度是不同的.
- 当输出力很高时,细胞可能会切换到具有较低ATP固态度的代谢途径.
- 这种"轮转换"可以增加ATP合成流量并维持生长,防止停止.
结论:
- 一个"多变"变速器转换策略可能是最适合生活系统的.
- 有机体利用多个代谢途径来实现轮转换.
- 这一策略允许有机体在代谢需求增加时适应和保持性能.
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