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[¹⁸F]FDG-PET/CT在异形性炎症肌肉病中:来自比利时队列的回顾性数据

Halil Yildiz¹, Charlotte Lepere², Giulia Zorzi³

¹Department of Internal Medicine and Infectious Diseases, Cliniques Universitaires Saint-Luc, Institute of Clinical and Experimental Research (IREC), Université Catholique de Louvain (UCLouvain), Avenue Hippocrate 10, B-1200 Brussels, Belgium.

Diagnostics (Basel, Switzerland)

|July 29, 2023

概括

[F]FDG-PET/CT成像有助于诊断炎症性肌肉病 (IIM) 和检测相关疾病,如间歇性肺病和癌症. 这项研究证实了其在欧洲队列中的有用性,将发现与其他诊断方法相关联.

科学领域:

核医学是一种核医学.
放射学放射学是一门学科.
类风湿病学类风湿病学
在瘤学瘤学.

背景情况:

异常性炎症性肌肉病变 (IIM),包括多质神炎 (PM) 和皮质神炎 (DM),是影响肌肉的罕见自身免疫性疾病.
用氧葡萄糖 (FDG) 的正子发射断层扫描/计算机断层扫描 (PET/CT) 已被公认为用于癌症检测和炎症成像.
关于[¹⁸F]FDG-PET/CT在IIM,特别是PM和DM中的实用性的欧洲数据有限.

研究的目的:

评估[¹⁸F]FDG-PET/CT在比利时一组疑似IIM患者的诊断性能.
评估[¹⁸F]FDG-PET/CT在检测IIM患者间歇性肺病 (ILD) 和恶性瘤方面的能力.
为了将肌肉吸收的FDG-PET/CT发现与电肌图 (EMG) 和磁共振成像 (MRI) 结果相关联.

主要方法:

追溯审查了2010年12月至2023年1月期间在比利时圣卢克大学诊所 (Cliniques Universitaires Saint-Luc) 住院的IIM病例.
分析FDG-PET/CT成像结果在29名确诊的IIM患者 (22个DM,7个PM).
将PET/CT检测结果与低剂量肺CT,EMG,MRI,血清肌激酶 (CK) 和C反应蛋白 (CRP) 水平进行比较.

主要成果:

[¹⁸F]FDG-PET/CT检测到7名患者的ILD (25.9%),3名患者的癌症 (11.1%),以及13名患者的异常肌肉吸收 (48.1%).
异常肌肉FDG吸收与阳性EMG (p=0.004) 和MRI (p=0.02) 结果显著相关.
肌肉吸收异常的患者显示CK水平显著更高 (p=0.008),呼吸障碍与PET/CT检测到的ILD相关 (p=0.002).

结论:

[¹⁸F]FDG-PET/CT是检测IIM患者的ILD和恶性瘤的一个有价值的工具.
在PET/CT上异常肌肉FDG吸收与EMG和MRI发现一致,支持其在诊断肌肉炎中的作用.
该研究强调了FDG-PET/CT在欧洲IIM队列中的实用性,有助于全面的患者评估.

关键词:

[18F]FDG-PET/CT/CT/FDG-PET/CT/CT/FDG-PET/CT/CT/CT/FDG-PET/CT/CT/FDG-PET/CT/CT/CT 癌症癌症癌症癌症癌症皮肤质神经炎 (dermatomyositis) 是一种疾病.异形性炎症性肌肉病变 (IIM) 是一种疾病.间歇性肺病间歇性肺病过多神经炎是一种多神经炎.

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