烟草吸烟与XPA和XPC基因多态性之间显著增加的风险关联
Safiah Almushawwah1, Mikhlid H Almutairi2, Abdullah M Alamri1
1Biochemistry Department, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.
Genes
|July 29, 2023
概括
吸烟 (CS) 与DNA损伤修复基因变异有关. 在XPA和XPC基因中的特定单核酸多态 (SNPs) 显示沙特吸烟者与疾病风险的关联.
科学领域:
- 遗传学 遗传学 是一个
- 分子生物学分子生物学
- 公共卫生 公共卫生
背景情况:
- 吸烟 (CS) 是许多疾病的重要风险因素,与基因组不稳定性有关.
- 核糖类可以损害DNA损伤修复系统,特别是核酸切除修复 (NER) 途径.
- 与CS相互作用的单核酸多态 (SNP) 可能通过影响NER通路功能来影响疾病易感性.
研究的目的:
- 调查XPA基因中的四个SNP和XPC基因中的四个SNP与沙特人口中吸烟的关联.
- 根据临床参数,确定这些遗传变异是否会改变CS相关疾病的风险.
主要方法:
- 一项涉及沙特人口201名健康吸烟者和220名健康非吸烟者的病例控制研究.
- 使用TaqMan测定方法对八个SNP (XPA中的四个:rs10817938, rs1800975, rs3176751, rs3176752;XPC中的四个:rs1870134, rs2228000, rs2228001, rs2607775) 进行基因型鉴定.
- 分析SNP与吸烟的临床参数 (持续时间,强度,年龄,性别) 之间的关联.
主要成果:
- 在XPA基因中,SNP rs3176751与所有临床参数的高风险有关. SNP rs1800975显示了低风险的关联. SNP rs10817938与长期吸烟者有高风险关联,与年轻吸烟者有低风险关联. SNP rs3176752显示,与老年吸烟者存在低风险关联.
- 在XPC基因中,SNP rs2228001在女性吸烟者中显示出低风险关联. SNP rs2607775与CS引起的疾病有显著的低风险关联,除男性吸烟者外.
- 在XPC基因中的sNPsrs2228000和rs1870134没有与CS.
结论:
- 香烟吸烟与DNA修复基因XPA和XPC中的多态性之间存在显著的风险增加和保护性关联.
- 在XPA和XPC中的特定SNP可能会调节个体对CS相关疾病的易感性.
- 需要进一步的研究来阐明这些基因与环境相互作用背后的精确机制.
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