牙周炎和慢性功能衰竭之间的遗传交叉对话被转录组分析揭示出来
Dandan Ren1, Thomas Ebert2, Deborah Kreher3
1School of Pharmacy, Nanjing Medical University, Nanjing 211166, China.
Genes
|July 29, 2023
概括
这项研究确定了五个关键基因 (CCL5,FCGR3B,MMP-9,SAA1,SELL) 链接牙周炎和慢性功能衰竭 (CKF). 这些基因主要参与炎症和血管过程,可能为这些疾病之间的关系提供新的见解.
科学领域:
- 生物信息学是一种生物信息学.
- 基因组学就是基因组学.
- 系统生物学 系统生物学
背景情况:
- 牙周炎和慢性功能衰竭 (CKF) 分享潜在的病因联系.
- 了解牙周炎和CKF之间的相互作用背后的分子机制对于开发向疗法至关重要.
研究的目的:
- 使用生物信息学方法识别潜在的交叉通话基因和牙周炎和CKF之间的相关途径.
- 确定可能调解这两种不同疾病之间的关系的关键基因.
主要方法:
- 使用基因表达综合 (GEO) 数据集用于牙周炎和DisGeNET用于CKF相关基因.
- 使用Cytoscape进行了差异基因表达分析,并构建了一个蛋白质-蛋白质相互作用 (PPI) 网络.
- 通过MCODE和LASSO回归分析确定了枢纽交叉通话基因.
主要成果:
- 在牙周炎中鉴定了489个差异表达基因 (DEGs) 和805个CKF相关基因.
- 在牙周炎和CKF之间发现了47个交叉通话基因的重叠.
- 确定了五个枢纽交叉交谈基因:CCL5,FCGR3B,MMP-9,SAA1和SELL,这些基因显著上调并显示出高预测值 (AUC≥73.44%).
结论:
- 已确定的枢纽基因 (CCL5,FCGR3B,MMP-9,SAA1,SELL) 可能参与牙周炎和CKF之间的相互作用.
- 炎症,代谢和心血管路径可能是这些疾病之间关系的关键调解者.
- 这些发现为了解牙周炎和CKF的并发症提供了分子基础.
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