与饮食和肠道微生物组改变有关的主要精神疾病中的表观遗传异常
Shabnam Nohesara1, Hamid Mostafavi Abdolmaleky1,2, Sam Thiagalingam1,3
1Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA 02218, USA.
Genes
|July 29, 2023
概括
营养和肠道微生物组影响大脑表观遗传学,影响心理健康. 了解这些肠-大脑轴相互作用是治疗精神障碍的新治疗策略的关键.
科学领域:
- 神经科学是一个神经科学.
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 微生物学 微生物学
背景情况:
- 营养和新陈代谢影响表观遗传修饰,如DNA甲基化和基因素乙化.
- 中枢神经系统 (CNS) 的这些表观遗传变化是由肠道微生物组通过肠-大脑轴调节的,影响神经元活动和行为.
- 肠道微生物组的遗传产品与人类表观遗传标记和基因有动态的相互作用.
研究的目的:
- 讨论肠道微生物组组成如何影响大脑表观遗传变化及其在精神疾病中的作用.
- 探索母亲饮食,营养,肠道微生物组和严重精神疾病中的表观遗传变化之间的相互作用.
- 通过表观遗传机制审查肠道微生物组,氧化应激,炎症和心理健康之间的联系.
主要方法:
- 文献综述和综合现有关于表观遗传学,肠道微生物组和心理健康的研究.
- 分析遗传构成,肠道微生物组,营养代谢和表观遗传景观之间的相互作用.
- 通过表观遗传修饰,检查肠道微生物群和益生菌对心理健康的影响的机制.
主要成果:
- 肠道微生物组的结构和组成显著塑造了大脑中的表观遗传变化.
- 母亲因素,营养和肠道微生物之间的相互作用可以通过表观遗传变化影响精神疾病的出现.
- 表观遗传机制将肠道微生物组与氧化应激,炎症和心理健康结果联系起来.
结论:
- 肠道微生物组在调节大脑表观遗传学和心理健康方面发挥着至关重要的作用.
- 了解肠-大脑-表观遗传轴为治疗精神疾病的新型治疗干预提供了潜力.
- 益生菌和营养干预可以通过表观遗传修饰来影响心理健康.
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