应用SHAP用于可解释的机器学习基于年龄分组的乳腺素检测问卷数据的应用,用于积极的乳腺素检测预测和风险因素识别
Jeffrey Sun1,2, Cheuk-Kay Sun3,4,5,6, Yun-Xuan Tang7,8
1Department of Acute Medicine, West Middlesex University Hospital, London TW7 6AF, UK.
Healthcare (Basel, Switzerland)
|July 29, 2023
概括
机器学习和SHAP分析从乳房扫描数据中确定了关键的乳腺癌风险因素. 初潮时的年龄,教育,性别平等,自我检查和BMI显著影响查结果.
科学领域:
- 在瘤学瘤学.
- 生物统计学 生物统计学
- 计算生物学 计算生物学
背景情况:
- 乳房摄影是乳腺癌查的主要工具.
- 了解乳腺癌风险因素至关重要,但仍有争议.
- 机器学习 (ML) 和SHAP为风险因素分析提供了先进的方法.
研究的目的:
- 利用ML和SHAP分析和排名乳腺癌风险因素.
- 为了比较不同年龄组风险因素的影响.
- 为了评估影响阳性乳房扫描结果的因素.
主要方法:
- 使用了参与乳腺癌查计划 (2017-2021) 的女性的数据.
- 应用了三个ML模型 (lasso,XGBoost,RF),其中Random Forest表现出卓越的性能.
- 与RF模型一起使用SHAP值来解释风险因子的显著性.
主要成果:
- 确定的前五个风险因素是初潮时的年龄,教育水平,性别平等,乳房自我检查和BMI.
- 生殖寿命和BMI影响的差异在年轻和年长的年龄组之间有所不同.
- SHAP分析提供了个性化的风险因素排名.
结论:
- ML和SHAP有效地识别和排名重要的乳腺癌风险因素.
- 可以生成个性化的风险因素概况,用于有针对性的查和预防.
- 这种方法支持了乳腺癌个性化医学的进步.
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