在炎症条件下持续暴露于噪音的影响
Inja Cho1,2, Jeongmin Kim1,2, Seungho Jung1,2
1Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.
Healthcare (Basel, Switzerland)
|July 29, 2023
概括
重症监护室 (ICU) 噪音暴露加剧了小鼠的败血症引起的认知障碍和焦虑. 这表明,控制噪音可以通过减少神经炎症和血脑屏障破坏来预防妄想.
科学领域:
- 神经科学是一个神经科学.
- 临界护理医学 临界护理医学
- 环境健康 环境健康
背景情况:
- 重症监护室 (ICU) 是一个杂的环境.
- 手术后痴呆症是重症患者常见的并发症.
- 在ICU中暴露于噪音可能有助于妄想的发展.
研究的目的:
- 在小鼠模型中研究ICU噪音对术后妄想的影响.
- 确定将噪音暴露,炎症和认知功能障碍联系在一起的机制.
- 提供关于ICU中的降噪策略的证据.
主要方法:
- 使用模仿ICU条件的小鼠模型,涉及脂多糖 (LPS) 诱导的败血症.
- 小鼠被暴露在75dB的噪音水平下.
- 评估了神经行为功能,神经炎症和血脑屏障 (BBB) 完整性.
主要成果:
- 暴露于噪音的败血症小鼠表现出增加的焦虑类行为和认知障碍.
- 在海马体中观察到显著的神经炎症和BBB干扰.
- 这些发现将噪音暴露与通过BBB损伤和炎症的认知缺陷联系在一起.
结论:
- 在全身炎症期间持续暴露于噪音会导致认知功能障碍和焦虑.
- 血脑屏障的破坏和神经炎症是关键的调解机制.
- 在ICU中调节噪音水平可能对预防妄想至关重要.
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