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检查Kratom菌株之间的精神活性差异

Guido Huisman^1,2, Maximilian Menke², Oliver Grundmann¹

¹Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL 32611, USA.

International journal of environmental research and public health

|July 29, 2023

概括

Kratom (Mitragyna speciosa) 用户报告了红色,绿色和白色菌株的不同影响,与营销一致. 然而,类化合物分析没有显示出显著的菌株差异,这表明营销和事报告可能会严重影响感知效应.

科学领域:

民族植物学民族植物学
药理学药理学是指药理学的学科.
神经科学是一个神经科学.

背景情况:

克拉 (Mitragyna speciosa) 是东南亚的一种植物,含有具有药理作用的类化合物.
在线供应商销售各种具有明显假定效果的kratom菌株.
关于 kratom 菌株效应的营销声称在很大程度上是没有根据的.

研究的目的:

调查不同颜色的kratom产品 (红色,绿色,白色) 是否会在使用者身上产生明显的自我报告效应.
为了比较用户报告的经验和动机在不同的kratom菌株.
评估报告的效应与实际的类化合物含量之间的关系.

主要方法:

在644名现有kratom用户中进行了匿名调查.
对红色,绿色和白色克拉菌株的自我报告影响和动机的比较.
从一个单一供应商的kratom产品中化物含量的分析.

主要成果:

调查受访者报告了不同克拉菌株的不同主观经验,与营销描述一致.
独立的实验室分析显示,类化合物含量没有显著的跨菌株差异.
报告的效果差异可能会受到营销叙述和事证据的不成比例的影响.

结论:

用户报告的克拉菌株效应与营销一致,但缺乏化物概况的客观支持.
营销和事报告对 kratom 感知效应的影响需要进一步调查.
未来的研究应该包括多样化的群体,多个供应商和受控研究,以探索安慰剂效应和其他因素,如小类化合物和类.

关键词:

7 - - 氧胺基尼因米特拉基纳特异性植物克拉托姆 (Kratom) 是一种这就是米特拉基尼因.精神活性化合物精神活性化合物

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