肝脏疾病是复发性高血症的危险因素:一项回顾性队列研究
Rebecca S Ahdoot1, Jui-Ting Hsiung1,2, Abiy Agiro3
1Division of Nephrology, Hypertension, and Kidney Transplantation, Department of Medicine, University of California Irvine, Irvine, CA 92868, USA.
Journal of clinical medicine
|July 29, 2023
概括
肝脏疾病显著增加了复发性高血症 (高) 的风险. 这一发现强调了监测肝病患者的水平的重要性.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 肝病学 肝病学是一种肝病学.
- 内部医学 内部医学
背景情况:
- 功能障碍的平衡与肝病有关,但其在高血症中的作用尚不清楚.
- 高血症 (血清>5.0 mmol/L) 构成严重的健康风险.
研究的目的:
- 为了研究肝病和复发性高胆固醇血症之间的关联.
- 为了确定肝脏疾病是否是复发性高血症的独立风险因素.
主要方法:
- 使用美国退伍军人事务数据库 (2004年1月 - 2018年12月) 进行的回顾性队列研究.
- 分析了1,493,539名患有发生性高血症的患者,确定了71,790名肝病患者.
- 竞争的风险回归模型来评估肝病和复发性高胆血症之间的关系.
主要成果:
- 复发性高卡利米亚发生在27.2%的肝病患者中,而没有肝病的患者则为15.1%.
- 肝脏疾病独立地与34%的复发性高血症风险增加有关 (SHR,1.34;95% CI,1.32-1.37;p < 0.0001).
- 这种关联持续不论是使用氨酸 - ангиотензин - 阿尔多斯特系统抑制剂或节性利尿剂,除了血管扩展剂治疗.
结论:
- 肝脏疾病是一个强烈的,独立的风险因素,在一年内复发的高血症.
- 密切监测水平对于肝病患者至关重要.
- 进一步的研究可能会探索具体的机制,将肝病与高胆血症联系起来.
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