系统性炎症 (AISI) 的综合指数,疾病严重程度和COVID-19中的死亡率:系统性审查和元分析
Angelo Zinellu1, Panagiotis Paliogiannis2,3, Arduino A Mangoni4,5
1Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy.
Journal of clinical medicine
|July 29, 2023
概括
综合系统性炎症指数 (AISI),使用血细胞计数,有效地识别严重的COVID-19病例并预测患者的生存率. 较高的AISI水平表明住院患者患重症或死亡的风险更高.
科学领域:
- 血液学 血液学 血液学
- 传染性疾病 传染性疾病
- 系统性炎症 系统性炎症
背景情况:
- 系统性炎症在COVID-19病变发生过程中至关重要.
- 血液细胞计数提供了对炎症的洞察力.
- 系统性炎症总指数 (AISI) 是一个新兴的生物标志物.
研究的目的:
- 在住院COVID-19患者中系统性炎症总指数 (AISI) 的系统性审查和元分析.
- 评估AISI与疾病严重程度和生存结果的关联.
- 评估AISI对严重的COVID-19的诊断性能.
主要方法:
- 对13项研究进行了系统审查和元分析.
- 包括住院COVID-19患者.
- 从中性粒细胞,单细胞,血小板和淋巴细胞计数得出的AISI分析.
- 对偏见风险和证据确定性的评估.
主要成果:
- 严重的COVID-19/死亡与入院时显著更高的AISI有关 (SMD = 0.68).
- AISI通过几率比率 (4.39) 显示了与严重疾病/死亡的显著关联.
- 针对严重疾病/死亡的综合诊断准确性:灵敏度为0.66,特异性为0.78,AUC为0.79.
结论:
- AISI是区分COVID-19严重程度和生存的一个有价值的工具.
- 入院时的AISI有效地预测了患者的结果.
- 这一指数有助于根据炎症标志物管理COVID-19患者.
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