非功能性上腺瘤是否会影响新陈代谢概况和心动脉内膜-介质厚度? 来自波兰的单一中心研究
Magdalena Szychlińska1, Magdalena Rzeczkowska2, Katarzyna Gontarz-Nowak1
1Clinic of Endocrinology, Diabetology and Internal Medicine, Department of Internal Medicine, School of Medicine, Collegium Medicum, University of Warmia and Mazury, 10-561 Olsztyn, Poland.
Journal of clinical medicine
|July 29, 2023
概括
患有非功能上腺偶发瘤 (NFAI) 的患者表现出心血管风险因素增加和早期动脉样硬化. 早期评估 carotid intima-media厚度 (CIMT) 对于检测这些个体的血管变化至关重要.
科学领域:
- 内分泌学 在内分泌学.
- 心血管医学 心血管医学
- 放射学 放射学是一门学科.
背景情况:
- 与普通人群相比,上腺意外瘤 (AIs) 与肥胖,高血压和代谢功能障碍的患病率更高有关.
- 这些条件是心血管改造和动脉样硬化的确立危险因素.
- 非功能性上腺意外瘤 (NFAI) 代表了一大批AI,需要进一步调查相关风险.
研究的目的:
- 调查NFAI,代谢概况和大脑动脉内膜介质厚度 (CIMT) 之间的关联.
- 评估CIMT作为NFAI患者动脉样硬化的预测因素.
- 在无症状的NFAI患者中识别早期血管改造.
主要方法:
- 一个研究队列包括48名患有NFAI的患者和44名匹配的对照,不包括以前患有心血管事件或糖尿病的人.
- 参与者接受了上腺成像,全面的生化评估和CIMT测量.
- 在AIs患者中进行了激素评估,包括1毫克德甲抑制试验.
主要成果:
- NFAI组表现出显著更高的腰围,静脉和腹血压,禁食胰岛素和口服后2小时的葡萄糖耐受性测试 (OGTT) 葡萄糖水平.
- 在NFAI组中,心动脉内膜介质厚度 (CIMT) 显著更高.
- 高血压和葡萄糖耐受性损害 (IGT) 在NFAI患者中更为普遍,CIMT和皮质醇水平在甲抑制测试后之间存在正相关性.
结论:
- 患有NFAI的患者表现出代谢异常和增加CIMT,即使在1毫克德甲测试后皮质醇抑制正常.
- Carotid intima-media 厚度 (CIMT) 评估对于在无症状 NFAI 患者中识别早期血管重塑是有价值的.
- 需要进一步的研究来阐明驱动这些心血管和代谢变化的潜在机制.
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