探索抗VEGF疗法与玻璃眼之间的关系:对管理策略的影响
Qëndresë Daka1,2,3, Nina Špegel3, Makedonka Atanasovska Velkovska3
1Department of Pathophysiology, Medical Faculty, University of Prishtina, 10000 Prishtina, Kosovo.
Journal of clinical medicine
|July 29, 2023
概括
重复的静脉内抗VEGF注射可能会导致持续的眼内压力 (IOP) 增加和二次玻璃眼. 本综述讨论了防止IOP升高的机制,风险因素和管理.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜疾病 视网膜疾病
- 玻璃眼研究研究 玻璃眼研究
背景情况:
- 内抗VEGF疗法是视网膜疾病的标准治疗方法.
- 暂时的眼内压力 (IOP) 升高是一种常见的副作用.
- 人们担心,在多次注射后,持续增加内皮压和发生二次玻璃眼病.
研究的目的:
- 为了审查持续的内皮血压升高的病理生理机制,在静脉内抗VEGF治疗后.
- 确定导致IOP增加的因素.
- 讨论风险患者的管理和治疗策略.
主要方法:
- 对内抗VEGF注射和IOP研究的文献综述.
- 报告的病理生理机制的分析.
- 综合当前的治疗和监测策略.
主要成果:
- 持续的IOP增加和继发性玻璃眼是反复注射抗VEGF的潜在风险.
- 危险因素包括先前存在的玻璃眼瘤,眼睛高血压,家族病史,高注射频率和囊切除术.
- 病理生理机制是多因素的,涉及药物配方和眼睛反应.
结论:
- 密切监测IOP对于接受反复内抗VEGF治疗的患者至关重要.
- 高风险患者需要量身定制,可调节的内压降压治疗.
- 需要积极的识别和管理策略,以防止持续的IOP升高和维护视觉功能.
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