重极化标记物中的性别差异:慢性心力衰竭患者的远程监测
Federica Moscucci1, Susanna Sciomer2, Silvia Maffei3
1Department of Internal Medicine and Medical Specialties, Policlinico Umberto I, Viale del Policlinico n. 155, 00161 Rome, Italy.
Journal of clinical medicine
|July 29, 2023
概括
电心电图 (ECG) 复极标记,特别是T峰到T端标准偏差 (TeSD),可以预测男性和女性的心力衰竭 (CHF) 的恶化. 然而,为了准确评估CHF患者的风险,可能需要特定于性别的值.
科学领域:
- 心脏病学 心脏病学
- 生物医学工程 生物医学工程
- 老年学是指老年学的学科.
背景情况:
- 衰老和慢性心力衰竭 (CHF) 导致心电图 (ECG) 上的时间复极异常.
- 再极化分散参数是急性失补偿和CHF死亡风险的新兴标志物.
- 已知心脏再极化中的基于性别的差异,但它们对心电图标志物的影响在CHF中未得到充分研究.
研究的目的:
- 为了研究心电图再极化标记的性别特异性差异,用于对心血管疾病患者的远程监测.
- 评估复极化参数在评估不补偿性心脏病发作和死亡风险方面的有用性.
主要方法:
- 收集了215名失补偿的CHF患者 (49-103岁) 的5分钟心电图记录.
- 评估QT末端 (QTe),QT峰值 (QTp) 和T峰到T末端 (Te) 的平均值和标准偏差 (SD).
- 通过30天死亡率或高NT-pro BNP水平来定义非补偿性CHF.
主要成果:
- 30天死亡率为16%,没有性别差异;女性的射出分数和脂质概况更好.
- 已故患者的Te平均值较高,但TeSD是两性中CHF复发的最可靠标志物.
- 在药物和设备使用方面注意到了性别特异性差异.
结论:
- T峰值到T端标准偏差 (TeSD) 是男性和女性心血管衰竭恶化的可靠风险因素.
- 对TeSD的性别特定切断值可能需要在CHF患者中进行最佳风险分层.
- 这项研究强调了在基于心电图的CHF监测中考虑性别的重要性.
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