日本人口中牙周状况和肝功能之间的关联:一个横截面研究
Toshiya Fujii1, Norio Aoyama1, Sayuri Kida1
1Department of Periodontology, Kanagawa Dental University, 82 Inaoka-cho, Yokosuka 238-8580, Kanagawa, Japan.
Journal of clinical medicine
|July 29, 2023
概括
严重的牙周病,以高牙周炎性表面积 (PISA) 为标志,与高马-胺转移酶 (GGT) 肝酶水平有关,特别是在男性中. 其他肝酶如AST和ALT没有受到PISA的显著影响.
科学领域:
- 口腔健康和全身疾病的联系 口腔健康和全身疾病的联系
- 牙周炎症中的生物标志物
- 肝病学和炎症性疾病
背景情况:
- 牙周炎与全身健康问题有关,包括肝脏功能障碍.
- 牙周炎症表面积 (PISA) 是系统性疾病的潜在指标.
- 关于PISA与特定肝功能标志物之间的关系的数据有限.
研究的目的:
- 为了研究肝功能标志物 (GGT,AST,ALT) 与PISA水平之间的关联.
- 为了确定PISA是否可以预测肝酶水平的变化.
- 探索这种关系中基于性别的潜在差异.
主要方法:
- 跨截面研究设计涉及从2018-2021年招募患者.
- 基于牙周临床检查的PISA计算.
- 从外周血液样本中测量血清GGT,AST和ALT水平.
主要成果:
- 与PISA高 (≥300 mm2) 的参与者相比,与PISA低 (<300 mm2) 的参与者相比,GGT水平显著增加.
- 在高和低PISA组之间没有观察到AST或ALT水平的显著差异.
- 特别是在PISA高的男性中观察到高的GGT.
结论:
- 高PISA与血清GGT水平升高有关,这表明牙周炎症和肝酶升高之间存在联系.
- AST和ALT水平似乎与PISA没有直接相关.
- 这些发现突出了GGT作为肝功能变化的潜在生物标志物,在具有重大牙周病的个体中,尤其是在男性中.
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