阿佩林-13作为危急疾病中的潜在生物标志物
Marin Gergics1,2, Gréta Pham-Dobor1,2, Csilla Kurdi2,3
11st Department of Internal Medicine, Medical School, University of Pécs, 7624 Pécs, Hungary.
血清阿佩林-13显示出作为危急疾病的预后生物标志物的潜力. 它与自由皮质醇一起,独立预测生存率,特别是在非败血症患者中.
科学领域:
- 内分泌学 在内分泌学.
- 关键护理医学 关键护理医学
- 生物标志物发现发现
背景情况:
- 上皮质系统和可佩是严重疾病的已确定的预后标志物.
- 在重症患者中,阿佩林-13的预测价值在很大程度上仍未被描述.
研究的目的:
- 为了研究apelin-13的预后作用.
- 为了将阿佩林-13与自由皮质醇,阿尔多,CRH和可佩作为生存预测因子进行比较.
主要方法:
- 对124名重症患者进行前性观察性研究.
- 血清阿佩林-13和其他激素水平与临床参数和生存结果的相关性.
主要成果:
- 血清阿佩林-13度在幸存者 (2477 pg/mL) 和非幸存者 (1161 pg/mL) 中较高,p=0.054.
- 阿佩林-13和CRH显示出强烈的正相关性 (r=0.685,p<0.001),并且在幸存的非败血症患者中更高.
- 在多变量分析中,阿佩林-13和自由皮质醇是生存的独立预测因素.
结论:
- 血清阿佩林-13可能会提高早期严重疾病的预后预测.
- 阿佩林-13除了提供自由皮质醇之外,还提供了额外的预后价值,特别是在非败血症患者中.
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