COVID-19和口腔平斑:在一个"有趣的阴谋"和"Fata Morgana效应"之间
Gaetano Scotto1, Vincenzina Fazio2, Salvatore Massa3
1Infectious Diseases Unit, University Hospital "OORR" Foggia, 71122 Foggia, Italy.
Journal of clinical medicine
|July 29, 2023
概括
由于SARS-CoV-2尖端蛋白暴露和相关的压力,COVID-19大流行可能会引发口腔平坦 (OLP). 需要进一步的研究来证实这种联系,并了解OLP.
科学领域:
- 免疫学 免疫学 免疫学
- 皮肤病学 皮肤病学
- 传染性疾病 传染性疾病
背景情况:
- COVID-19 流行病已经呈现出除了呼吸系统症状之外的各种临床表现.
- 口腔平坦 (OLP) 是一种慢性炎症状况,与免疫失调和各种触发因素有关.
- 感染SARS-CoV-2和与流行病相关的压力是影响OLP的潜在新因素.
研究的目的:
- 探索COVID-19 (SARS-CoV-2) 与口腔平坦菌 (OLP) 的发病或恶化之间的潜在关联.
- 调查SARS-CoV-2尖端蛋白和心理压力的OLP病变发生中的作用.
- 突出诊断挑战和进一步研究COVID-19-OLP连接的需要.
主要方法:
- 对将COVID-19与OLP联系起来的临床观察的审查.
- 在OLP中讨论涉及SARS-CoV-2尖端蛋白和TRIM21的免疫机制.
- 考虑心理压力作为一个促成因素.
主要成果:
- 暴露于SARS-CoV-2尖端蛋白可能会诱导引发OLP的自身免疫反应.
- 在OLP病变和COVID-19患者中,TRIM21的过度表达表明存在潜在的免疫学联系.
- 锁定/隔离导致的心理压力可能会加剧OLP.
结论:
- COVID-19 感染和与流行病相关的压力是口腔平的潜在触发因素.
- E3酶TRIM21可能在COVID-19和OLP之间的相互作用中发挥作用.
- 进一步调查对于阐明COVID-19和OLP之间的复杂关系至关重要,有助于诊断和治疗.
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