老年人的血管精神分裂症类精神病
Michele Lauriola1, Grazia D'Onofrio2, Filomena Ciccone2
1Complex Unit of Geriatrics, Department of Medical Sciences, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, 71013 Foggia, Italy.
Journal of clinical medicine
|July 29, 2023
概括
这项研究分析了患有非常晚发性精神分裂症类精神病 (VLOSLP) 的老年人血管风险因素. 研究结果显示,男性和女性有不同的模式,这表明血管健康和精神病之间存在联系.
科学领域:
- 老年精神病学是一门精神病学专业.
- 血管神经学 血管神经学
- 临床心理学 临床心理学
背景情况:
- 非常晚发的精神分裂症类精神病 (VLOSLP) 影响的是老年人.
- 了解血管风险因素对于VLOSLP管理至关重要.
- 需要基于病理生理学的表型,而不仅仅是年龄.
研究的目的:
- 分析VLOSLP.老年患者血管风险因素的患病率和严重程度.
- 根据病理生理学的见解,开发一种特定的VLOSLP表型.
- 探索血管事件和VLOSLP之间的潜在联系.
主要方法:
- 在103名患者的长度研究 (平均年龄为80.32岁).
- 评估包括认知,神经精神和功能评估.
- 测量了血液标志物 (Hb,MCV,脂质等) 并收集了有关生活方式和病史 (吸烟,高血压,糖尿病) 的数据.
主要成果:
- 女性表现出比男性更高的冷漠.
- 男性的血红蛋白和尿酸水平较高,血小板和水平较低,烟草/酒精使用率较高.
- 在男性中,在不同年龄组 (<80岁与≥80岁) 之间观察到血管风险因素的差异.
结论:
- 结果可能支持心脏/脑血管事件和VLOSLP.之间的因果关系.
- 突出了VLOSLP内血管风险概况的潜在基于性别的差异.
- 建议进一步研究VLOSLP的病理生理基础.
相关概念视频
Schizophrenia
139
Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
139
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
748
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
748
Positive Symptoms of Schizophrenia: Hallucinations and Delusions
176
Schizophrenia is a complex mental health disorder that can manifest with various positive symptoms, including thought, movement, and behavior disorders. These symptoms significantly disrupt cognitive and motor functions, leading to profound effects on an individual's ability to engage with the world.
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes...
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes...
176
Psychological and Sociocultural Causes of Schizophrenia
139
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
139
Cognitive Development During Adulthood
158
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
158
Psychosis and Antipsychotic Drugs: Overview
331
The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic...
331


