心血管风险因素对心脏性休克30天全因死亡率的影响
Jan Forner1,2, Tobias Schupp1,2, Kathrin Weidner1,2
1Department of Cardiology, Angiology, Haemostaseology and Medical Intensive Care, University Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany.
Journal of clinical medicine
|July 29, 2023
概括
心血管风险因素不会影响心脏性休克 (CS) 患者的短期死亡率. 整体风险和个人因素,如高血压,糖尿病或吸烟,与CS患者的30天存活率没有显著关联.
科学领域:
- 心脏病学 心脏病学
- 关键护理医学 关键护理医学
- 流行病学 流行病学
背景情况:
- 心血管风险 (CVR) 因素在急性冠状动脉综合征中得到了充分研究,但它们对心脏性休克 (CS) 预后的影响不明.
- 关于CVR因素如何影响CS患者的死亡率的数据有限.
研究的目的:
- 调查CS患者中CVR因子数量与30天全因死亡率之间的关联.
- 评估动脉高血压,糖尿病,高脂血症和吸烟对CS预后的个人影响.
主要方法:
- 从2019-2021年开始对273名连续CS患者进行前性队列研究.
- 患者被分为低CVR (0-1因素) 和高CVR (2-4因素) 组.
- 卡普兰-梅尔和考克斯回归分析被用来评估30天死亡率,调整为共变量.
主要成果:
- 高CVR (72%) 与低CVR (28%) 相比,没有显著增加30天死亡率 (55%对57%,p=0.738).
- 包括动脉高血压,糖尿病和吸烟史在内的个人因素没有显著影响短期预后.
- 只有缺乏高脂血症的情况显示出死亡率下降的趋势 (p=0.049),但在调整后失去了意义.
结论:
- 整体心血管风险负担与心脏性休克患者的30天死亡率无关.
- 个体心血管风险因素在这个患者群体中并不能显著预测短期结果.
- 可能需要进一步的研究来确定CS.死亡率的具体预测因素.
相关概念视频
Blood Pressure Imbalances and Circulatory Shock
812
Disorders affecting blood volume, vascular tone, or vascular function can disrupt vascular homeostasis, including conditions like hypertension, hemorrhage, and shock.
Blood Pressure: Hypertension and Hypotension
Normal blood pressure is 120/80 mm Hg. Elevated blood pressure is 120-129/under 80 mm Hg. Hypertension, warranting treatment at 130/80 mm Hg, is often asymptomatic and can lead to severe cardiovascular events, aneurysms, peripheral arterial disease, chronic renal disease, or cardiac...
Blood Pressure: Hypertension and Hypotension
Normal blood pressure is 120/80 mm Hg. Elevated blood pressure is 120-129/under 80 mm Hg. Hypertension, warranting treatment at 130/80 mm Hg, is often asymptomatic and can lead to severe cardiovascular events, aneurysms, peripheral arterial disease, chronic renal disease, or cardiac...
812
Heart Failure I: Introduction
16
Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
16
Pathophysiology of Cardiac Performance
706
Typical heart performance is influenced by heart rate, rhythm, myocardial contraction, and metabolism or blood flow. The cardiac muscle exhibits distinct electrophysiological features, including pacemaker activity and calcium channel control, which play a vital role in the heart's response to various drugs. The autonomic nervous system, comprising the sympathetic and parasympathetic branches, regulates heart rate. Sympathetic activation increases heart rate, while parasympathetic activation...
706
Imbalances in Cardiac Output
1.4K
The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
1.4K
Coronary Artery Disease III: Clinical Manifestations
13
Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
13
Psychoneuroimmunology: Cardiovascular Disease
52
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
52


