暴露体对眼睛表面疾病的影响
Merrelynn Hong1, Louis Tong1,2,3, Jodhbir S Mehta1,3,4
1Corneal and External Diseases Department, Singapore National Eye Centre, Singapore 168751, Singapore.
International journal of molecular sciences
|July 29, 2023
概括
环境因素,称为曝光体,显著影响眼睛表面疾病 (OSDs). 本综述探讨了包括眼部微生物组在内的外部和内部暴露体如何导致OSD和炎症.
科学领域:
- 眼科和环境健康
背景情况:
- 眼睛表面疾病 (OSD) 导致显著的眼睛发病率,导致炎症,不适和潜在的视力丧失.
- 严重的OSD包括眼表面衰竭,包括肢体干细胞缺乏和角膜变化.
- 暴露体,包括外部 (如污染) 和内部 (如微生物群) 环境因素,越来越多地与OSD相关联.
研究的目的:
- 审查目前关于暴露体在各种眼睛表面疾病中的作用的证据.
- 探索眼睛表面微生物组与OSD病原体之间的联系.
- 了解环境因素如何导致眼睛表面炎症和痕.
主要方法:
- 对暴露体和眼睛表面疾病的现有科学文献的综述.
- 分析利用元基因组学和下一代测序进行微生物组分析的研究.
- 综合了外部和内部暴露对眼睛健康的影响的数据.
主要成果:
- 在OSD患者中,经常报告眼表面微生物组的变化.
- 微生物组的变化可能是OSD的原因或后果.
- 外部和内部暴露体都与OSDs的发展和进展有关.
结论:
- 了解曝光体-OSD相互作用对于识别致病因素至关重要.
- 眼睛表面微生物组在OSD病原发生过程中发挥着潜在的重要作用.
- 对曝光体的进一步研究可以指导眼睛表面炎症和痕的管理.
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