抗精神病药物影响卫星III (1q12) 在培养的人类皮肤纤维细胞的复制数变化
Elizaveta S Ershova1, Ekaterina A Savinova1, Larisa V Kameneva1
1Research Centre for Medical Genetics, 1 Moskvorechye St., 115522 Moscow, Russia.
International journal of molecular sciences
|July 29, 2023
概括
抗精神病药物,包括哈洛佩里多尔 (haloperidol),里斯佩里 (risperidone) 和奥兰扎 (olanzapine),可以降低人体皮肤纤维细胞中的卫星DNA (f-SatIII). 这种减少与DNA损伤的减少和自的增加有关,这表明一种新的治疗机制.
科学领域:
- 遗传学 是一个遗传学.
- 细胞生物学 细胞生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 卫星III (f-SatIII) 碎片存在于染色体1的周心基异色染色体中.
- 扩大的f-SatIII块与细胞应激易感性和不响应性有关.
- 精神分裂症患者细胞中的f-SatIII水平随着抗精神病治疗而波动.
研究的目的:
- 研究常见抗精神病药物 (haloperidol,risperidone, olanzapine) 对人类皮肤纤维细胞中的f-SatIII含量的影响.
- 探索f-SatIII水平,DNA损伤和细胞过程 (如亡和自) 之间的相关性.
主要方法:
- 人体皮肤纤维细胞系 (n=10) 用抗精神病药物治疗了3,24小时和96小时.
- 使用非放射性杂交方法量化f-SatIII DNA 含量.
- 通过RT-qPCR测量f-SatIII (RNASATIII) 的RNA水平.
- 通过流细胞计分析了DNA损伤标记物 (8-oxodG, γ-H2AX) 和亡/自蛋白.
主要成果:
- 抗精神病药物显著降低了纤维细胞中的f-SatIII DNA和RNASATIII RNA水平.
- 自标志物LC3增加,而亡标志物在抗精神病药物暴露后减少.
- f-SatIII DNA 含量与 RNASATIII 和 DNA 氧化 (8-oxodG) 有正相关,与 LC3.3 有负相关.
结论:
- 抗精神病药物抑制了培养纤维细胞中的f-SatIII重复扩张.
- 这种抑制似乎是通过转录抑制和/或增强的自介导消除具有扩大f-SatIII块的细胞而发生的.
关键词:
8-oxodG的使用情况.在CNV中,CNV是NV.在HSF中,HSF是HSF.LC3 LC3 LC3 LC3 的意思是什么意思三星三号的转录抗精神病治疗的治疗方法.抗精神病药物 抗精神病药物卫星III 卫星III 是一个卫星.精神分裂症是一种精神分裂症.γH2AXX 的时间.更多相关视频
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