相关实验视频
Updated: Jun 19, 2026
07:44
Analysis of Fatty Acid Content and Composition in Microalgae
Published on: October 1, 2013
60.2K
通过从微藻中提取的脂质提取物预防UVB诱导的表皮细胞代谢变化Nannochloropsis oceanica
Anna Stasiewicz1, Tiago Conde2,3, Agnieszka Gęgotek1
1Department of Analytical Chemistry, Medical University of Bialystok, Kilinskiego 1, 15-069 Bialystok, Poland.
International journal of molecular sciences
|July 29, 2023
概括
来自Nannochloropsis oceanica的脂质提取物可以保护人类皮肤细胞免受UVB损伤. 它减少氧化应激和炎症,保持正常的皮肤细胞代谢.
科学领域:
- 皮肤病学 皮肤病学
- 生物技术是生物技术.
- 海洋生物学 海洋生物学
背景情况:
- 紫外线辐射会诱导皮肤细胞的氧化应激和炎症.
- 人类角质细胞容易受到UVB诱导的损伤.
- 微藻提取物被探索为光保护性质.
研究的目的:
- 评估从Nannochloropsis oceanica中提取的脂质提取物的保护作用,以防止UVB诱导的人类角质细胞的损伤.
- 调查提取物对氧化应激标志物和炎症通路的影响.
主要方法:
- 人类角质细胞被暴露在UVB辐射中.
- 用Nanochloropsis oceanica脂质提取物进行治疗.
- 对细胞活力,酶活性 (亲氧化和抗氧化),活性氧物种 (ROS) 水平,Nrf2通路组件,膜载体和炎症媒介 (TNFα,8-异质前列腺素F2,4-HNE) 的测试.
主要成果:
- 提取物显著降低了UVB诱导的细胞死亡.
- 它降低了亲氧化酶活性和ROS水平,同时增加了抗氧化酶活性.
- 提取物调节了Nrf2通路激活器和沉默了UVB过度表达的膜载体.
- 观察到抗炎作用,TNFα水平降低,8-异构前列腺素F2和4-HNE蛋白添加物.
结论:
- 海洋的脂质成分提取物 Nannochloropsis oceanica 提供显著的保护,防止UVB诱导的皮细胞的氧化和炎症效应.
- 提取物有助于稳定UVB暴露破坏的皮肤细胞代谢.
- 海洋的提取物显示出作为天然光保护剂的潜力.
更多相关视频
12:37Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
Published on: September 7, 2013
18.3K
10:05Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ
Published on: May 8, 2020
2.0K
相关概念视频
01:35Mutations
Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors. Mutations can be characterized in a number of different ways: whether and how they alter the amino acid sequence of the protein, whether they occur over a small or large area of DNA, and whether they occur in somatic cells or germline cells.
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...
01:38Nucleotide Excision Repair
DNA Distortion and Damage
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
01:23Role of Skin in Vitamin D Synthesis
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin D3(cholecalciferol).
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin D3(cholecalciferol).
01:19Pigmentation
The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
01:30Skin Cancer
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
01:25Biofuels
The microbial conversion of organic matter into biofuels holds potential as a renewable energy source. Among biofuel sources, microalgae are recognized as a highly efficient and adaptable feedstock for biodiesel production, owing to their rapid biomass accumulation, elevated lipid productivity, and capacity to proliferate in diverse aquatic systems, including freshwater, marine, and wastewater habitats. Unlike terrestrial crops, microalgae do not compete for land and can achieve significantly...