金属纳米材料和基于水解酶的配方,以提高抗真菌活性
Ilya Lyagin1, Aysel Aslanli1, Maksim Domnin1
1Faculty of Chemistry, Lomonosov Moscow State University, Lenin Hills 1/3, 119991 Moscow, Russia.
International journal of molecular sciences
|July 29, 2023
概括
结合金属化合物和酶提供了一种有前途的策略来打击抗真菌耐药性. 这种方法利用金属杆.
科学领域:
- 生物化学 生物化学
- 菌类学 菌类学是指菌类学.
- 材料科学 材料科学 材料科学
背景情况:
- 增加抗真菌耐药性需要新的治疗策略.
- 含有金属的化合物和酶被探索为潜在的抗真菌剂.
- 金属提供各种各样的配体选项,包括来自绿色合成的配体.
研究的目的:
- 审查结合金属基化合物和酶用于抗真菌治疗的潜力.
- 探索金属和酶对真菌病原体的协同作用.
- 研究金属对酶活性的影响,反之亦然.
主要方法:
- 关于金属抗真菌化合物和基于酶的抗真菌机制的现有文献的审查.
- 分析金属产生的活性氧物种 (ROS).
- 评估水解酶对真菌细胞结构和毒性因子的影响.
主要成果:
- 金属主要通过诱导活性氧物种 (ROS) 生成而起作用.
- 像葡萄糖酶和蛋白酶这样的酶会破坏真菌细胞壁,膜和生物膜.
- 金属和酶的组合为抗真菌治疗提供了多方面的方法.
结论:
- 将金属化合物和酶结合在一起,显示出克服抗真菌耐药性的显著前景.
- 需要进一步的研究来阐明协同相互作用,并优化组合疗法.
- 这种双重方法可能会导致对酵母和菌根真菌的更有效的治疗方法.
关键词:
他们的6-OPH.MOFs 的使用情况.粉样蛋白质是粉样蛋白质的蛋白质.生物膜是一种生物膜.这里是奇特的Chitinases.绿色合成是一种绿色合成.增长抑制 增长抑制乳糖类的乳腺体.乳腺癌患者的治疗方法菌类毒素 (mycotoxins) 是一种有毒的物质.酸是什么 酸是什么议员数量限制的灭.议员数量检测是指对议员数量进行检测.更多相关视频
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