耐力运动诱导的Fgf21通过TGF-β1和p38 MAPK信号通路促进骨肌纤维的转化
Xiaomao Luo1, Huiling Zhang1, Xiaorui Cao1
1College of Veterinary Medicine, Shanxi Agricultural University, Jinzhong 030801, China.
International journal of molecular sciences
|July 29, 2023
概括
纤维细胞生长因子21 (Fgf21) 在耐力运动中起着关键作用.
科学领域:
- 运动生理学 运动生理学
- 分子生物学分子生物学
- 骨肌肉生物学 骨肌肉生物学
背景情况:
- 耐力运动对骨肌肉的适应有深远的影响.
- 纤维细胞生长因子21 (Fgf21) 在运动诱导的骨肌肉变化中的特定作用尚不清楚.
- 研究Fgf21的贡献对于理解肌肉可塑性至关重要.
研究的目的:
- 阐明Fgf21在耐力运动期间骨肌肉纤维类型转换中的作用.
- 探索Fgf21影响肌肉适应训练的分子机制.
- 评估Fgf21作为肌肉健康的治疗点的潜力.
主要方法:
- 对耐力训练的野生型和Fgf21淘汰赛小鼠进行比较分析.
- 评估肌肉大小,功能和纤维类型标记物 (免疫组织化学,免疫块,qPCR).
- 使用C2C12细胞进行体外研究,以调查Fgf21信号通路 (lentivirus,通路抑制剂).
主要成果:
- 耐力运动增加了肝脏和GAS肌肉中的Fgf21水平,提高了运动能力.
- 骨肌肉纤维尺寸分布减少,快的纤维转化为慢的纤维.
- 通过抑制TGF-β1信号和激活p38 MAPK信号,Fgf21促进了纤维类型的转换.
结论:
- 在应对耐力训练时,Fgf21调解了骨肌肉纤维类型的转变.
- Fgf21的下游信号通路对于运动诱导的肌肉适应至关重要.
- Fgf21具有改善肌肉健康和对抗疲劳的潜力.
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